Your browser doesn't support javascript.
loading
Genetic risk factors for venous thrombosis in women using combined oral contraceptives: update of the PILGRIM study.
Suchon, P; Al Frouh, F; Ibrahim, M; Sarlon, G; Venton, G; Alessi, M-C; Trégouët, D-A; Morange, P-E.
Afiliación
  • Suchon P; AIx Marseille Univ, INSERM, INRA, NORT, Marseille, France.
  • Al Frouh F; APHM, Hôpital de la Timone, Service d'hématologie biologique, Marseille, France.
  • Ibrahim M; APHM, Hôpital de la Timone, Service d'hématologie biologique, Marseille, France.
  • Sarlon G; AIx Marseille Univ, INSERM, INRA, NORT, Marseille, France.
  • Venton G; APHM, Hôpital de la Timone, Service d'hématologie biologique, Marseille, France.
  • Alessi MC; Médecine vasculaire et Hypertension artérielle, Faculté de Médecine de Marseille, Aix-Marseille Université, Assistance Publique Hôpitaux de Marseille - Hôpital de La Timone, Marseille, France.
  • Trégouët DA; INSERM, UMR1090 TAGC, Aix-Marseille University, Marseille, France.
  • Morange PE; Service d'hématologie, APHM, Hôpital de la Conception, Marseille, France.
Clin Genet ; 91(1): 131-136, 2017 01.
Article en En | MEDLINE | ID: mdl-27414984
Identifying women at risk of venous thrombosis (VT) under combined oral contraceptives (COC) is a major public health issue. The aim of this study was to investigate in COC users the impact on disease of genetic polymorphisms recently identified to associate with VT risk in the general population. Nine polymorphisms located on KNG1, F11, F5, F2, PROCR, FGG, TSPAN and SLC44A2 genes were genotyped in a sample of 766 patients and 464 controls as part of the PILGRIM (PILl Genetic Risk Monitoring) study. Cases were women who experienced an episode of documented VT during COC use, while controls were women with no history of VT using COC at the time of inclusion. Among the studied polymorphisms, only F11 rs2289252 was significantly associated with VT. The F11 rs2289252-A allele was associated with a 1.6-fold increased risk of VT (p < 0.0001). Besides, the combination of the rs2289252-A allele with non-O blood group, present in 52% of the cohort, was associated with an odds ratio of 4.00 (2.49-6.47; p < 10-4 ). The consideration of this genetic risk factor could help to better assess the risk of VT in COC users.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticonceptivos Orales Combinados / Trombosis de la Vena / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Clin Genet Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticonceptivos Orales Combinados / Trombosis de la Vena / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Clin Genet Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Dinamarca