Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.

Perry, Rachel J; Cardone, Rebecca L; Petersen, Max C; Zhang, Dongyan; Fouqueray, Pascale; Hallakou-Bozec, Sophie; Bolze, Sébastien; Shulman, Gerald I; Petersen, Kitt Falk; Kibbey, Richard G

Perry, Rachel J; Cardone, Rebecca L; Petersen, Max C; Zhang, Dongyan; Fouqueray, Pascale; Hallakou-Bozec, Sophie; Bolze, Sébastien; Shulman, Gerald I; Petersen, Kitt Falk; Kibbey, Richard G.

Afiliación

Perry RJ; Departments of Internal Medicine and.
Cardone RL; Departments of Internal Medicine and.
Petersen MC; Departments of Internal Medicine and Cellular and Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut;
Zhang D; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut;
Fouqueray P; Poxel SA, Paris, France; and.
Hallakou-Bozec S; Poxel SA, Paris, France; and.
Bolze S; Poxel SA, Paris, France; and.
Shulman GI; Departments of Internal Medicine and Cellular and Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut; Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark.
Petersen KF; Departments of Internal Medicine and Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark.
Kibbey RG; Departments of Internal Medicine and Cellular and Molecular Physiology and richard.kibbey@yale.edu.

Am J Physiol Endocrinol Metab ; 311(2): E461-70, 2016 08 01.

Article en En | MEDLINE | ID: mdl-27406738

Asunto(s)

Glucemia/efectos de los fármacos; Hipoglucemiantes/farmacología; Células Secretoras de Insulina/efectos de los fármacos; Insulina/metabolismo; Triazinas/farmacología; Animales; Glucemia/metabolismo; Dieta Alta en Grasa; Ayuno; Glucosa/metabolismo; Técnica de Clampeo de la Glucosa; Resistencia a la Insulina; Secreción de Insulina; Células Secretoras de Insulina/metabolismo; Hígado/efectos de los fármacos; Hígado/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Periodo Posprandial; Ratas; Ratas Sprague-Dawley

Palabras clave

glucose-stimulated insulin secretion; imeglimin; ß-cell

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Glucemia / Células Secretoras de Insulina / Hipoglucemiantes / Insulina Límite: Animals Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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