Free radical reactions involving the angiotensin converting enzyme inhibitor captopril.

Forni, L G; Hilton, P J; Willson, R L; Cheeseman, K H

Forni, L G; Hilton, P J; Willson, R L; Cheeseman, K H.

Afiliación

Forni LG; a Department of Renal and Intensive Care Medicine , St Thomas' Hospital , London , UK.
Hilton PJ; a Department of Renal and Intensive Care Medicine , St Thomas' Hospital , London , UK.
Willson RL; b Department of Biology and Biochemistry , Brunel University , Uxbridge , UK.
Cheeseman KH; b Department of Biology and Biochemistry , Brunel University , Uxbridge , UK.

Redox Rep ; 2(6): 393-9, 1996 Dec.

Article en En | MEDLINE | ID: mdl-27406674

RESUMEN

Using the pulse radiolysis technique, absolute rate constants have been obtained for the reaction of captopril with several free radicals. The results demonstrate that although captopril reacts rapidly with a number of free radicals, such as the hydroxyl radical (k = 5.1 × 10(9) dm(-3)mol(-1)s(-1)) and the thiocyanate radical anion (k = 1.3 × 10(7) dm(-3)mol(-1)s(-1)), it is not exceptional in this ability. Similarly, the reactions with carbon centred radicals although rapid are an order of magnitude slower than those observed with glutathione. Additional lipid peroxidation studies further demonstrate that captopril is a much less effective antioxidant than glutathione. The data go some way to supporting the view that any attenuation of reperfusion injury by captopril is not through a direct free radical scavenging mechanism but may be afforded by other, non-radical-mediated mechanisms.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Redox Rep Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 1996 Tipo del documento: Article Pais de publicación: Reino Unido

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