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Neuroprotective Effects of Pregabalin on Cerebral Ischemia and Reperfusion.
Asci, Sanem; Demirci, Serpil; Asci, Halil; Doguç, Duygu Kumbul; Onaran, Ibrahim.
Afiliación
  • Asci S; Neurology Service, Gülkent State Hospital, Isparta, Turkey.
  • Demirci S; Department of Neurology, Süleyman Demirel University School of Medicine, Isparta, Turkey.
  • Asci H; Department of Pharmacology, Süleyman Demirel University School of Medicine, Isparta, Turkey.
  • Doguç DK; Department of Biochemistry, Süleyman Demirel University School of Medicine, Isparta, Turkey.
  • Onaran I; Department of Medical Biology and Genetic, Süleyman Demirel University School of Medicine, Isparta, Turkey.
Balkan Med J ; 33(2): 221-7, 2016 Mar.
Article en En | MEDLINE | ID: mdl-27403394
BACKGROUND: Stroke is one of the most common causes of death and the leading cause of disability in adults. Cerebral ischemia/reperfusion injury causes cerebral edema, hemorrhage, and neuronal death. AIMS: In post-ischemic reperfusion, free radical production causes brain tissue damage by oxidative stress. Pregabalin, an antiepileptic agent was shown to have antioxidant effects. The aim of this study was to evaluate the neuroprotective and antioxidant effects of pregabalin on ischemia and reperfusion in rat brain injury. STUDY DESIGN: Animal experimentation. METHODS: Male Wistar rats weighing (250-300 g) were randomly divided into six groups, each consisting of 6 rats: control (C), pregabalin (P), ischemia (I), pregabalin + ischemia (PI), ischemia + reperfusion (IR) and ischemia + reperfusion + pregabalin (PIR). Rats were initially pre-treated with 50 mg/kg/d pregabalin orally for two days. Then, animals that applied ischemia in I, PI, IR and PIR groups were exposed to carotid clamping for 30 minutes and 20 minutes reperfusion was performed in the relevant reperfusion groups. RESULTS: NR2B receptor levels were significantly lower in the PIR group in comparison to the IR group. In the PIR group, Thiobarbituric acid reactive substance (TBARS) level had statistically significant decrease compared with IR group. Glutathione peroxidase (GSH-PX) levels were also significantly increased in the PIR group compared with I, IR and control groups. In the PI and PIR groups, catalase (CAT) levels were also significantly increased compared with I and IR groups (p=0.03 and p=0.07, respectively). CONCLUSION: Pregabalin may protect the damage of oxidative stress after ischemia + reperfusion. This result would illuminate clinical studies in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Balkan Med J Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Balkan Med J Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía