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Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation.
Rovera, Chiara; Mauri, Massimo Carlo; Bertin, Elena; Di Pace, Chiara; Paletta, Silvia; Reggiori, Alessandra; De Gaspari, Ilaria Francesca; Cattaneo, Dario; Mari, Daniela; Altamura, Alfredo Carlo.
Afiliación
  • Rovera C; Department of Neuroscience and Mental Health, Clinical Psychiatry, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy. chiara.rovera@libero.it.
  • Mauri MC; Department of Neuroscience and Mental Health, Clinical Psychiatry, Clinical Psychopharmacology Unit, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  • Bertin E; Geriatric Unit, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  • Di Pace C; Department of Neuroscience and Mental Health, Clinical Psychiatry, Clinical Psychopharmacology Unit, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  • Paletta S; Department of Neuroscience and Mental Health, Clinical Psychiatry, Clinical Psychopharmacology Unit, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  • Reggiori A; Department of Neuroscience and Mental Health, Clinical Psychiatry, Clinical Psychopharmacology Unit, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  • De Gaspari IF; Department of Neuroscience and Mental Health, Clinical Psychiatry, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  • Cattaneo D; Unit of Clinical Pharmacology, L. Sacco University Hospital, Milan, Italy.
  • Mari D; Geriatric Unit, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  • Altamura AC; Department of Neuroscience and Mental Health, Clinical Psychiatry, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
Hum Psychopharmacol ; 31(5): 349-55, 2016 09.
Article en En | MEDLINE | ID: mdl-27400882
OBJECTIVE: The aim of this open-label naturalistic study was to assess clinical outcomes and the predictive value of duloxetine plasma levels in major depressive disorder in the elderly. METHODS: This naturalistic, open-label design involved 35 outpatients aged between 65 and 87 years. Duloxetine plasma levels were collected in 24 patients after the first month. Patients were evaluated using 21-item Hamilton Rating Scales for Depression, Hamilton Rating Scales for Anxiety, the Clinical Global Impression Severity, Mini Mental State Examination, Cumulative Illness Rating Scale, Barthel Index and Beck's Depression Inventory. RESULTS: Duloxetine plasma levels at T2 ranged from 4.9 to 201.9 ng/mL without a significant correlation between duloxetine dose and plasma levels. A significant improvement in mean 21-item Hamilton Rating Scales for Depression total scores at T2,T3, T4, T9 and T12 and a progressive significantly decrease of the mean Hamilton Rating Scales for Anxiety scores from T3 to T12 were observed. CONCLUSIONS: The levels of duloxetine in plasma do not correlate with a greater clinical improvement, indeed appear to adversely affect the improvement of the Beck Depression Inventory and Hamilton Rating Scales for Anxiety. This could be explained by an increase in side effects that may aggravate the discomfort felt by the patient. Copyright © 2016 John Wiley & Sons, Ltd.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Clorhidrato de Duloxetina / Inhibidores de Captación de Serotonina y Norepinefrina Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Hum Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Clorhidrato de Duloxetina / Inhibidores de Captación de Serotonina y Norepinefrina Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Hum Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido