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Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.
Gomez-Quiroz, Luis E; Seo, Daekwan; Lee, Yun-Han; Kitade, Mitsuteru; Gaiser, Timo; Gillen, Matthew; Lee, Seung-Bum; Gutierrez-Ruiz, Ma Concepcion; Conner, Elizabeth A; Factor, Valentina M; Thorgeirsson, Snorri S; Marquardt, Jens U.
Afiliación
  • Gomez-Quiroz LE; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA; Departamento de Ciencias de la Salud, Universidad Autonoma Metropolitana Iztapalapa, Mexico, DF, Mexico.
  • Seo D; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Lee YH; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA; Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, South Korea.
  • Kitade M; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Gaiser T; Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany.
  • Gillen M; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Lee SB; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Gutierrez-Ruiz MC; Departamento de Ciencias de la Salud, Universidad Autonoma Metropolitana Iztapalapa, Mexico, DF, Mexico.
  • Conner EA; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Factor VM; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Thorgeirsson SS; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Marquardt JU; 1st Department of Medicine, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. Electronic address: marquarj@uni-mainz.de.
Toxicology ; 361-362: 39-48, 2016 06 15.
Article en En | MEDLINE | ID: mdl-27394961
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colestasis Intrahepática / Estrés Oxidativo / Proteínas Proto-Oncogénicas c-met / Hepatocitos / Lípidos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxicology Año: 2016 Tipo del documento: Article País de afiliación: México Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colestasis Intrahepática / Estrés Oxidativo / Proteínas Proto-Oncogénicas c-met / Hepatocitos / Lípidos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxicology Año: 2016 Tipo del documento: Article País de afiliación: México Pais de publicación: Irlanda