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Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro.
Luty, Marcin; Kwiecien, Edyta; Firlej, Magdalena; Labedz-Maslowska, Anna; Paw, Milena; Madeja, Zbigniew; Czyz, Jaroslaw.
Afiliación
  • Luty M; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Kwiecien E; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Firlej M; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Labedz-Maslowska A; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Paw M; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Madeja Z; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Czyz J; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
Acta Biochim Pol ; 63(3): 397-401, 2016.
Article en En | MEDLINE | ID: mdl-27390785
Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on the Walker-256 cells. It also strengthened the inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained viability after a long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mitoxantrona / Curcumina Límite: Animals Idioma: En Revista: Acta Biochim Pol Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mitoxantrona / Curcumina Límite: Animals Idioma: En Revista: Acta Biochim Pol Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia