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SLC6A4 promoter region methylation and socio-emotional stress response in very preterm and full-term infants.
Montirosso, Rosario; Provenzi, Livio; Giorda, Roberto; Fumagalli, Monica; Morandi, Francesco; Sirgiovanni, Ida; Pozzoli, Uberto; Grunau, Ruth; Oberlander, Tim F; Mosca, Fabio; Borgatti, Renato.
Afiliación
  • Montirosso R; 0-3 Center for the at-Risk Infant, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, LC, Italy.
  • Provenzi L; 0-3 Center for the at-Risk Infant, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, LC, Italy.
  • Giorda R; Molecular Biology Laboratory, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, LC, Italy.
  • Fumagalli M; NICU, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Morandi F; Pediatric Unit, Sacra Famiglia Hospital, Erba, CO, Italy.
  • Sirgiovanni I; NICU, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Pozzoli U; Bioinformatic Lab, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, LC, Italy.
  • Grunau R; Department of Pediatrics, University of British Columbia, & Child & Family Research Institute, Vancouver, BC, Canada.
  • Oberlander TF; Department of Pediatrics, University of British Columbia, & Child & Family Research Institute, Vancouver, BC, Canada.
  • Mosca F; NICU, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Borgatti R; Neuropsychiatry & Neurorehabilitation Unit, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, LC, Italy.
Epigenomics ; 8(7): 895-907, 2016 07.
Article en En | MEDLINE | ID: mdl-27381173
AIM: The present study is part of a prospective micro-longitudinal research project and reports on the association between SLC6A4 methylation and socio-emotional stress response in very preterm (VPT) and full-term (FT) infants. MATERIALS & METHODS: SLC6A4 methylation was assessed at birth and discharge in 32 VPT infants, and at birth in 27 FT infants. Socio-emotional stress response (i.e., negative emotionality) was assessed at 3 months (corrected age). RESULTS: Negative emotionality was higher in VPTs compared with FT counterpart. In VPT infants only, stress response was associated with SLC6A4 methylation status at discharge, which was predictive of greater negative emotionality. CONCLUSION: The present study extends previous reports, suggesting that altered SLC6A4 methylation associates with greater socio-emotional stress sensitivity in 3-month-old VPT infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Proteínas de Transporte de Serotonina en la Membrana Plasmática Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Epigenomics Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Proteínas de Transporte de Serotonina en la Membrana Plasmática Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Epigenomics Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido