Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.

Kapeli, Katannya; Pratt, Gabriel A; Vu, Anthony Q; Hutt, Kasey R; Martinez, Fernando J; Sundararaman, Balaji; Batra, Ranjan; Freese, Peter; Lambert, Nicole J; Huelga, Stephanie C; Chun, Seung J; Liang, Tiffany Y; Chang, Jeremy; Donohue, John P; Shiue, Lily; Zhang, Jiayu; Zhu, Haining; Cambi, Franca; Kasarskis, Edward; Hoon, Shawn; Ares, Manuel; Burge, Christopher B; Ravits, John; Rigo, Frank; Yeo, Gene W

Kapeli, Katannya; Pratt, Gabriel A; Vu, Anthony Q; Hutt, Kasey R; Martinez, Fernando J; Sundararaman, Balaji; Batra, Ranjan; Freese, Peter; Lambert, Nicole J; Huelga, Stephanie C; Chun, Seung J; Liang, Tiffany Y; Chang, Jeremy; Donohue, John P; Shiue, Lily; Zhang, Jiayu; Zhu, Haining; Cambi, Franca; Kasarskis, Edward; Hoon, Shawn; Ares, Manuel; Burge, Christopher B; Ravits, John; Rigo, Frank; Yeo, Gene W.

Afiliación

Kapeli K; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Pratt GA; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Vu AQ; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Hutt KR; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Martinez FJ; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Sundararaman B; Department of Bioinformatics and Systems Biology, University of California at San Diego, La Jolla, California 92093, USA.
Batra R; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Freese P; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Lambert NJ; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Huelga SC; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Chun SJ; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Liang TY; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Chang J; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Donohue JP; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Shiue L; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Zhang J; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Zhu H; Department of Neurosciences, University of California at San Diego, La Jolla, California 92093, USA.
Cambi F; Department of Biology, MIT, Cambridge, Massachusetts 02142, USA.
Kasarskis E; Department of Biology, MIT, Cambridge, Massachusetts 02142, USA.
Hoon S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Ares M; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Burge CB; Department of Bioinformatics and Systems Biology, University of California at San Diego, La Jolla, California 92093, USA.
Ravits J; Ionis Pharmaceuticals, Carlsbad, California 92010, USA.
Rigo F; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Yeo GW; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA.

Nat Commun ; 7: 12143, 2016 07 05.

Article en En | MEDLINE | ID: mdl-27378374

Asunto(s)

Empalme Alternativo/genética; Esclerosis Amiotrófica Lateral/genética; Proteínas de Unión al ADN/genética; Proteína FUS de Unión a ARN/genética; Factores Asociados con la Proteína de Unión a TATA/genética; Regiones no Traducidas 3'/genética; Animales; Biología Computacional/métodos; Proteínas de Unión al ADN/metabolismo; Modelos Animales de Enfermedad; Femenino; Fibroblastos; Técnicas de Silenciamiento del Gen; Secuenciación de Nucleótidos de Alto Rendimiento/métodos; Humanos; Células Madre Pluripotentes Inducidas; Intrones/genética; Ratones; Ratones Endogámicos C57BL; Neuronas Motoras/metabolismo; Mutación; Oligonucleótidos Antisentido/administración & dosificación; Oligonucleótidos Antisentido/genética; Cultivo Primario de Células; ARN Mensajero/genética; ARN Mensajero/metabolismo; ARN Interferente Pequeño/metabolismo; Proteína FUS de Unión a ARN/metabolismo; Análisis de Secuencia de ARN/métodos; Factores Asociados con la Proteína de Unión a TATA/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Empalme Alternativo / Proteína FUS de Unión a ARN / Factores Asociados con la Proteína de Unión a TATA / Proteínas de Unión al ADN / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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