Structural and Physicochemical Studies of Olopatadine Hydrochloride Conformational Polymorphs.
J Pharm Sci
; 105(8): 2419-26, 2016 08.
Article
en En
| MEDLINE
| ID: mdl-27373838
Crystal and molecular structures of 2 conformational polymorphs (forms I and II) of olopatadine hydrochloride, an antiallergic agent, are presented. Both crystal modifications crystallize in the monoclinic crystal system with 1 olopatadine hydrochloride molecule in the Z configuration in the asymmetric unit. Molecules are arranged into the centrosymmetric association through the interactions of the intermolecular strong and weak hydrogen bonds of N-H
Cl, O-H
Cl and C-H
Cl, C-H
O types. Conformational change between polymorphs is proved by calculations of a maximum torsion angle deviation (max[Δθ]) and a root-mean-square deviation between the atomic positions (rmsd[r]). The physicochemical characterization of polymorphs is performed by X-ray powder diffraction, infrared and Raman spectroscopy, differential scanning calorimetry. The comparison of the melting points and heats of fusions shows that the forms are monotropically related.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antialérgicos
/
Clorhidrato de Olopatadina
/
Modelos Químicos
Idioma:
En
Revista:
J Pharm Sci
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Estados Unidos