Your browser doesn't support javascript.
loading
Efficacy and tolerability of a combined lipid-lowering nutraceutical on cholesterolemia, hs-CRP level and endothelial function in moderately hypercholesterolemic subjects.
Cicero, A F; Colletti, A; Rosticci, M; Grandi, E; Borghi, C.
Afiliación
  • Cicero AF; Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy.
  • Colletti A; Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy.
  • Rosticci M; Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy.
  • Grandi E; Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy.
  • Borghi C; Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy.
J Biol Regul Homeost Agents ; 30(2): 593-8, 2016.
Article en En | MEDLINE | ID: mdl-27358154
Our aim was to test, by a double-blind, placebo-controlled randomized clinical trial, whether a short-term treatment with a combined lipid-lowering nutraceutical could improve endothelial function in a cohort of moderately hypercholesterolemic subjects. Thus, 80 healthy, moderately hypercholesterolemic subjects were consecutively enrolled and, after 4 weeks of stabilization diet, they were randomized to either the tested lipid-lowering nutraceutical or placebo for 8 weeks. At the beginning and end of treatment a complete lipid pattern, safety parameters, hs-CRP and endothelial function were measured. When compared to placebo, during nutraceutical treatment patients experienced a more favorable percentage change in total cholesterol (TC vs baseline: -17.9%; TC vs placebo: -5.6%), LDL-cholesterol (LDL-C vs baseline: -23.3%; LDL-C vs placebo: -2.8%), hs-CRP (hs-CRP vs baseline: -2.4%; hs-CRP vs placebo: -1.5%), and endothelial function (pulse volume displacement vs baseline: +17%; pulse volume displacement vs placebo treatment: -3.3%). No significant difference was observed in respect to effects on triglycerides, HDL-cholesterol and safety parameters. On the basis of our data, the tested lipid-lowering nutraceutical seems to significantly improve endothelial function in moderately hypercholesterolemic subjects. These results have to be confirmed on larger patient samples and over longer periods.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Endotelio Vascular / Suplementos Dietéticos / Hipercolesterolemia / Hipolipemiantes Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Biol Regul Homeost Agents Asunto de la revista: BIOLOGIA / BIOQUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Endotelio Vascular / Suplementos Dietéticos / Hipercolesterolemia / Hipolipemiantes Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Biol Regul Homeost Agents Asunto de la revista: BIOLOGIA / BIOQUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia