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Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Guaitoli, Giambattista; Raimondi, Francesco; Gilsbach, Bernd K; Gómez-Llorente, Yacob; Deyaert, Egon; Renzi, Fabiana; Li, Xianting; Schaffner, Adam; Jagtap, Pravin Kumar Ankush; Boldt, Karsten; von Zweydorf, Felix; Gotthardt, Katja; Lorimer, Donald D; Yue, Zhenyu; Burgin, Alex; Janjic, Nebojsa; Sattler, Michael; Versées, Wim; Ueffing, Marius; Ubarretxena-Belandia, Iban; Kortholt, Arjan; Gloeckner, Christian Johannes.
Afiliación
  • Guaitoli G; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;
  • Raimondi F; Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy; Cell Networks, University of Heidelberg, 69120 Heidelberg, Germany;
  • Gilsbach BK; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Department of Cell Biochemistry, University of Groningen, Groningen 9747 AG, The Netherlands; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227 Dortmund, Germany;
  • Gómez-Llorente Y; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
  • Deyaert E; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Vlaams Instituut voor Biotechnologie, Structural Biology Research Center, Vrije Universiteit Brussel, 1050 Brussels, Belgium;
  • Renzi F; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
  • Li X; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
  • Schaffner A; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
  • Jagtap PK; Center for Integrated Protein Science Munich at Department of Chemistry, Technische Universität München, 85747 Garching, Germany; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Munich, Germany;
  • Boldt K; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;
  • von Zweydorf F; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;
  • Gotthardt K; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227 Dortmund, Germany;
  • Lorimer DD; Beryllium Discovery Corporation, Bainbridge Island, WA 98110;
  • Yue Z; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
  • Burgin A; Broad Institute, Cambridge, MA 02142;
  • Janjic N; SomaLogic, Boulder, CO 80301.
  • Sattler M; Center for Integrated Protein Science Munich at Department of Chemistry, Technische Universität München, 85747 Garching, Germany; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Munich, Germany;
  • Versées W; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Vlaams Instituut voor Biotechnologie, Structural Biology Research Center, Vrije Universiteit Brussel, 1050 Brussels, Belgium;
  • Ueffing M; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;
  • Ubarretxena-Belandia I; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de.
  • Kortholt A; Department of Cell Biochemistry, University of Groningen, Groningen 9747 AG, The Netherlands; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de.
  • Gloeckner CJ; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de.
Proc Natl Acad Sci U S A ; 113(30): E4357-66, 2016 07 26.
Article en En | MEDLINE | ID: mdl-27357661
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Moleculares / Multimerización de Proteína / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Dominios Proteicos Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Moleculares / Multimerización de Proteína / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Dominios Proteicos Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos