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CD101: a novel long-acting echinocandin.
Zhao, Yanan; Perez, Winder B; Jiménez-Ortigosa, Cristina; Hough, Grayson; Locke, Jeffrey B; Ong, Voon; Bartizal, Ken; Perlin, David S.
Afiliación
  • Zhao Y; Public Health Research Institute, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Newark, NJ, USA.
  • Perez WB; Public Health Research Institute, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Newark, NJ, USA.
  • Jiménez-Ortigosa C; Public Health Research Institute, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Newark, NJ, USA.
  • Hough G; Cidara Therapeutics, Inc., San Diego, CA, USA.
  • Locke JB; Cidara Therapeutics, Inc., San Diego, CA, USA.
  • Ong V; Cidara Therapeutics, Inc., San Diego, CA, USA.
  • Bartizal K; Cidara Therapeutics, Inc., San Diego, CA, USA.
  • Perlin DS; Public Health Research Institute, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Newark, NJ, USA.
Cell Microbiol ; 18(9): 1308-16, 2016 09.
Article en En | MEDLINE | ID: mdl-27354115
CD101 is a novel echinocandin drug being developed to treat severe fungal infections including invasive candidiasis. We have performed a series of studies to evaluate the antifungal properties of CD101 against both echinocandin-susceptible and -resistant Candida strains. Antifungal susceptibility testing performed on a collection of 95 Candida strains including 30 caspofungin-resistant isolates containing fks mutations demonstrated comparable antifungal potency of CD101 relative to micafungin (MCF) across different Candida species. Comparable kinetic inhibition of glucan synthase activity was also observed for CD101 and MCF on both wild-type (WT) and resistant fks mutant Candida strains. Similarly, both drugs yielded nearly identical values for a mutant prevention concentration. In a murine model of invasive candidiasis, CD101 displayed better or at least comparable efficacy relative to MCF in treating WT or fks mutant Candida albicans. An exceptional long-lived pharmacokinetic profile was observed in mice following a single dose of CD101. Collectively, CD101 has great potential not only in treating invasive Candida infections but also in preventing emergence of resistance to currently approved echinocandin drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis / Equinocandinas / Antifúngicos Límite: Animals Idioma: En Revista: Cell Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis / Equinocandinas / Antifúngicos Límite: Animals Idioma: En Revista: Cell Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: India