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Aligned nanofibrillar collagen scaffolds - Guiding lymphangiogenesis for treatment of acquired lymphedema.
Hadamitzky, Catarina; Zaitseva, Tatiana S; Bazalova-Carter, Magdalena; Paukshto, Michael V; Hou, Luqia; Strassberg, Zachary; Ferguson, James; Matsuura, Yuka; Dash, Rajesh; Yang, Phillip C; Kretchetov, Shura; Vogt, Peter M; Rockson, Stanley G; Cooke, John P; Huang, Ngan F.
Afiliación
  • Hadamitzky C; Clinic of Plastic, Esthetic and Hand Surgery, Helios Clinic Hildesheim, Hildesheim 31135, Germany.
  • Zaitseva TS; Clinic of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover 30625, Germany.
  • Bazalova-Carter M; Fibralign Corporation, Union City, California 94587, USA.
  • Paukshto MV; Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA.
  • Hou L; Department of Physics and Astronomy, University of Victoria, Victoria, British Columbia V8P5C2, Canada.
  • Strassberg Z; Fibralign Corporation, Union City, California 94587, USA.
  • Ferguson J; Stanford Cardiovascular Institute, Stanford University, Stanford, California 94305, USA.
  • Matsuura Y; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA.
  • Dash R; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA.
  • Yang PC; Surpass Inc., Mountain View, California 94043, USA.
  • Kretchetov S; Division of Cardiovascular Medicine, Stanford University, Stanford, California 94305, USA.
  • Vogt PM; Division of Cardiovascular Medicine, Stanford University, Stanford, California 94305, USA.
  • Rockson SG; Division of Cardiovascular Medicine, Stanford University, Stanford, California 94305, USA.
  • Cooke JP; IntraOp Medical Corporation, Sunnyvale, California 94085, USA.
  • Huang NF; Clinic of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover 30625, Germany.
Biomaterials ; 102: 259-267, 2016 09.
Article en En | MEDLINE | ID: mdl-27348849
Secondary lymphedema is a common disorder associated with acquired functional impairment of the lymphatic system. The goal of this study was to evaluate the therapeutic efficacy of aligned nanofibrillar collagen scaffolds (BioBridge) positioned across the area of lymphatic obstruction in guiding lymphatic regeneration. In a porcine model of acquired lymphedema, animals were treated with BioBridge scaffolds, alone or in conjunction with autologous lymph node transfer as a source of endogenous lymphatic growth factor. They were compared with a surgical control group and a second control group in which the implanted BioBridge was supplemented with exogenous vascular endothelial growth factor-C (VEGF-C). Three months after implantation, immunofluorescence staining of lymphatic vessels demonstrated a significant increase in lymphatic collectors within close proximity to the scaffolds. To quantify the functional impact of scaffold implantation, bioimpedance was used as an early indicator of extracellular fluid accumulation. In comparison to the levels prior to implantation, the bioimpedance ratio was significantly improved only in the experimental BioBridge recipients with or without lymph node transfer, suggesting restoration of functional lymphatic drainage. These results further correlated with quantifiable lymphatic collectors, as visualized by contrast-enhanced computed tomography. They demonstrate the therapeutic potential of BioBridge scaffolds in secondary lymphedema.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colágeno / Factor C de Crecimiento Endotelial Vascular / Linfangiogénesis / Andamios del Tejido / Nanofibras / Linfedema Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomaterials Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colágeno / Factor C de Crecimiento Endotelial Vascular / Linfangiogénesis / Andamios del Tejido / Nanofibras / Linfedema Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomaterials Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos