Impact of glycoprotein B genotype and naturally occurring ORF UL56 polymorphisms upon susceptibility of clinical human cytomegalovirus isolates to letermovir.
Antiviral Res
; 132: 204-9, 2016 08.
Article
en En
| MEDLINE
| ID: mdl-27345658
Letermovir is a novel anti-HCMV drug in Phase III development that targets the UL56 subunit of the viral terminase complex. In immunocompromised patients four major glycoprotein B (gB) subtypes are known and may influence pathogenesis and thus disease outcomes. Using a panel of 74 letermovir-naïve, low-passage, clinical HCMV isolates, we examined the potential impact of i) gB genotype and ii) naturally occurring UL56 sequence variations upon susceptibility to letermovir. Our data show that letermovir's potency is independent of gB subtype and show that naturally-occurring letermovir-resistance is rare or possibly absent.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
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Polimorfismo Genético
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Quinazolinas
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Proteínas Estructurales Virales
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Proteínas del Envoltorio Viral
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Infecciones por Citomegalovirus
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Citomegalovirus
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Genotipo
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Acetatos
Límite:
Humans
Idioma:
En
Revista:
Antiviral Res
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Países Bajos