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A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Sison-Young, Rowena L; Lauschke, Volker M; Johann, Esther; Alexandre, Eliane; Antherieu, Sébastien; Aerts, Hélène; Gerets, Helga H J; Labbe, Gilles; Hoët, Delphine; Dorau, Martina; Schofield, Christopher A; Lovatt, Cerys A; Holder, Julie C; Stahl, Simone H; Richert, Lysiane; Kitteringham, Neil R; Jones, Robert P; Elmasry, Mohamed; Weaver, Richard J; Hewitt, Philip G; Ingelman-Sundberg, Magnus; Goldring, Chris E; Park, B Kevin.
Afiliación
  • Sison-Young RL; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
  • Lauschke VM; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • Johann E; Early Non-Clinical Safety, Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Alexandre E; KaLy-Cell, 20A rue du Général Leclerc, 67115, Plobsheim, France.
  • Antherieu S; Université de Lille 2, EA 4483, Lille, France.
  • Aerts H; Biologie Servier, 905 Rue de Saran, 45520, Gidy, France.
  • Gerets HHJ; UCB BioPharma SPRL, Non-Clinical Development, Chemin du Foriest, 1420, Braine-l'Alleud, Belgium.
  • Labbe G; Sanofi-Aventis Recherche and Développement, Drug Safety Evaluation, Alfortville, France.
  • Hoët D; Sanofi-Aventis Recherche and Développement, Drug Safety Evaluation, Alfortville, France.
  • Dorau M; Sanofi-Aventis Deutschland GmbH, R&D DSAR, Preclinical Safety FF, Industriepark Hoechst, Building H823, Room 104, 65926, Frankfurt am Main, Germany.
  • Schofield CA; GSK, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Lovatt CA; GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK.
  • Holder JC; GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK.
  • Stahl SH; AstraZeneca, Innovative Medicines and Early Development, Drug Safety and Metabolism, ADME Transporters, Unit 310 - Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0FZ, UK.
  • Richert L; KaLy-Cell, 20A rue du Général Leclerc, 67115, Plobsheim, France.
  • Kitteringham NR; Université de Franche-Comté, EA 4267, 25030, Besançon, France.
  • Jones RP; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
  • Elmasry M; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
  • Weaver RJ; North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK.
  • Hewitt PG; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
  • Ingelman-Sundberg M; North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK.
  • Goldring CE; Biologie Servier, 905 Rue de Saran, 45520, Gidy, France.
  • Park BK; Early Non-Clinical Safety, Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.
Arch Toxicol ; 91(3): 1385-1400, 2017 Mar.
Article en En | MEDLINE | ID: mdl-27344343
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Toxicidad Aguda / Enfermedad Hepática Inducida por Sustancias y Drogas Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Arch Toxicol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Toxicidad Aguda / Enfermedad Hepática Inducida por Sustancias y Drogas Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Arch Toxicol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Alemania