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Di-nor- and 17-nor-pimaranes from Icacina trichantha.
Guo, Brian; Onakpa, Monday M; Huang, Xiao-Jun; Santarsiero, Bernard D; Chen, Wei-Lun; Zhao, Ming; Zhang, Xiao-Qi; Swanson, Steven M; Burdette, Joanna E; Che, Chun-Tao.
Afiliación
  • Guo B; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
  • Onakpa MM; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
  • Huang XJ; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja , Abuja 920001, Nigeria.
  • Santarsiero BD; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632, People's Republic of China.
  • Chen WL; Center for Biomolecular Sciences and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago , Chicago, Illinois 60607, United States.
  • Zhao M; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
  • Zhang XQ; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
  • Swanson SM; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632, People's Republic of China.
  • Burdette JE; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
  • Che CT; School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
J Nat Prod ; 79(7): 1815-21, 2016 07 22.
Article en En | MEDLINE | ID: mdl-27340832
Six new pimarane derivatives, including two di-nor-pimaranes (1, 2), two 17-nor-pimaranes (3, 4), and two 17-nor-(9ß-H)-pimaranes (5, 6), were isolated from the tuber of Icacina trichantha. Their structures were elucidated based on spectroscopic and HRMS data. The absolute configurations of 1 and 5 were determined by single-crystal X-ray diffraction, and that of 2 was established by electronic circular dichroism data analysis. Compound 3 possesses a unique C-20 acetal moiety. This is the first report of the isolation of di-nor-(9ß-H)-pimarane derivatives from Icacina plants. Compounds 5 and 6 showed moderate cytotoxicity against MDA-MB-435, MDA-MB-231, and OVCAR3 cell lines, with IC50 values of 2.91-7.60 and 1.48-3.23 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Magnoliopsida / Abietanos Idioma: En Revista: J Nat Prod Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Magnoliopsida / Abietanos Idioma: En Revista: J Nat Prod Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos