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The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients.
Menon, Saras; Nasir, Bushra; Avgan, Nesli; Ghassabian, Sussan; Oliver, Christopher; Lea, Rodney; Smith, Maree; Griffiths, Lyn.
Afiliación
  • Menon S; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Nasir B; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Avgan N; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Ghassabian S; Centre for Integrated Preclinical Drug Development Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
  • Oliver C; Blackmores Institute, 20 Jubilee Avenue, Warriewood, NSW 2102, Australia.
  • Lea R; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Smith M; Centre for Integrated Preclinical Drug Development Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
  • Griffiths L; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. lyn.griffiths@qut.edu.au.
J Headache Pain ; 17(1): 60, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27339806
BACKGROUND: Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid. METHODS: This was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B6 and Vitamin B12, on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura. RESULTS: Vitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels (P = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention (P > 0.1). CONCLUSION: 1 mg of folic acid in combination with vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B6 and 400 µg of vitamin B12.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Suplementos Dietéticos / Migraña con Aura / Vitamina B 6 / Ácido Fólico Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Middle aged Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Suplementos Dietéticos / Migraña con Aura / Vitamina B 6 / Ácido Fólico Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Middle aged Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido