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Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.
Jarvis, David; Mitchell, Jonathan S; Law, Philip J; Palin, Kimmo; Tuupanen, Sari; Gylfe, Alexandra; Hänninen, Ulrika A; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Kaprio, Jaakko; Eriksson, Johan G; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Järvinen, Heikki; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Meklin, Jukka-Pekka; Al-Tassan, Nada A; Palles, Claire; Martin, Lynn; Barclay, Ella; Farrington, Susan M; Timofeeva, Maria N; Meyer, Brian F; Wakil, Salma M; Campbell, Harry; Smith, Christopher G; Idziaszczyk, Shelley; Maughan, Timothy S; Kaplan, Richard; Kerr, Rachel; Kerr, David; Buchanan, Daniel D; Win, Aung K; Hopper, John L; Jenkins, Mark A; Lindor, Noralane M; Newcomb, Polly A; Gallinger, Steve; Conti, David; Schumacher, Fred.
Afiliación
  • Jarvis D; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
  • Mitchell JS; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
  • Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
  • Palin K; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Tuupanen S; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Gylfe A; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Hänninen UA; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Cajuso T; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Tanskanen T; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Kondelin J; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Kaasinen E; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Sarin AP; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Kaprio J; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Eriksson JG; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Rissanen H; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Knekt P; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Pukkala E; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Jousilahti P; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
  • Salomaa V; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Ripatti S; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
  • Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
  • Järvinen H; National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Renkonen-Sinisalo L; National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Lepistö A; Folkhälsan Research Centre, Helsinki 00250, Finland.
  • Böhm J; Unit of General Practice and Primary Health Care, University of Helsinki, Helsinki University Hospital, Helsinki 00014, Finland.
  • Meklin JP; National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Al-Tassan NA; National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Palles C; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki 00130, Finland.
  • Martin L; School of Health Sciences, University of Tampere, Tampere 33014, Finland.
  • Barclay E; National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Farrington SM; National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Timofeeva MN; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
  • Meyer BF; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
  • Wakil SM; Department of Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Campbell H; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Smith CG; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Idziaszczyk S; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki 00029, Finland.
  • Maughan TS; Department of Surgery, Abdominal Center, Helsinki University Hospital Helsinki 00029, Finland.
  • Kaplan R; Department of Surgery, Abdominal Center, Helsinki University Hospital Helsinki 00029, Finland.
  • Kerr R; Department of Pathology, Central Finland Central Hospital, Jyväskylä 40620, Finland.
  • Kerr D; Department of Surgery, Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä 40620, Finland.
  • Buchanan DD; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
  • Win AK; Wellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
  • Hopper JL; Wellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
  • Jenkins MA; Wellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
  • Lindor NM; Colon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
  • Newcomb PA; The Roslin Institute, University of Edinburgh, Easter Bush, Roslin, Edinburgh EH25 9RG, UK.
  • Gallinger S; Colon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
  • Conti D; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
  • Schumacher F; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
Br J Cancer ; 115(2): 266-72, 2016 Jul 12.
Article en En | MEDLINE | ID: mdl-27336604
BACKGROUND: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. METHODS: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls. RESULTS: In the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02-1.49, P=0.033), 1.59 (95% CI: 1.08-2.34, P=0.019) and 1.07 (95% CI: 1.03-1.13, P=0.018), respectively. There was no evidence for association between birth weight and CRC (OR=1.22, 95% CI: 0.89-1.67, P=0.22). Combining these data with a concurrent MR-based analysis for BMI and WHR with CRC risk (totalling to 18 190 cases, 27 617 controls) provided increased support, ORs for BMI and WHR were 1.26 (95% CI: 1.10-1.44, P=7.7 × 10(-4)) and 1.40 (95% CI: 1.14-1.72, P=1.2 × 10(-3)), respectively. CONCLUSIONS: These data provide further evidence for a strong causal relationship between adiposity and the risk of developing CRC highlighting the urgent need for prevention and treatment of adiposity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adiposidad Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adiposidad Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido