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Spatial and Temporal Brain Responses to Noxious Heat Thermal Stimuli in Burning Mouth Syndrome.
Shinozaki, T; Imamura, Y; Kohashi, R; Dezawa, K; Nakaya, Y; Sato, Y; Watanabe, K; Morimoto, Y; Shizukuishi, T; Abe, O; Haji, T; Tabei, K; Taira, M.
Afiliación
  • Shinozaki T; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan Clinical Research Division, Nihon University Dental Research Center, Tokyo, Japan.
  • Imamura Y; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan Clinical Research Division, Nihon University Dental Research Center, Tokyo, Japan imamura.yoshiki@nihon-u.ac.jp.
  • Kohashi R; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Dezawa K; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Nakaya Y; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Sato Y; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Watanabe K; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Morimoto Y; Division of Oral and Maxillofacial Radiology, Kyushu Dental University, Kitakyushu, Japan.
  • Shizukuishi T; Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
  • Abe O; Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
  • Haji T; Brain Activity Imaging Center, ATR-Promotions Inc., Osaka, Japan.
  • Tabei K; Department of Dementia Prevention and Therapeutics, Mie University Graduate School of Medicine, Tsu, Japan.
  • Taira M; Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan.
J Dent Res ; 95(10): 1138-46, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27302878
Burning mouth syndrome (BMS) is an idiopathic orofacial pain condition. Although the pathophysiology of BMS is not clearly understood, central and peripheral neuropathic mechanisms are thought to be involved. The authors compared brain response to noxious heat stimuli in 16 right-handed women with primary BMS and 15 sex- and age-matched right-handed healthy female controls. A thermal stimulus sequence of 32 °C to 40 °C to 32 °C to 49 °C was repeated 4 times in a cycle. Warm and noxious heat stimuli were delivered with a Peltier thermode placed on the right palm or right lower lip for 32 s each in a session. Functional magnetic resonance imaging data were obtained by recording echoplanar images with a block design. Statistical Parametric Mapping 8 software was used to analyze the data. Patients and controls both reported feeling more pain during palm stimulation than during lip stimulation. Repetition of noxious heat stimulus on the lower lip but not on the palm induced habituation in brain activity in the cingulate cortex without reduction in pain perception. Multiple regression analysis revealed a correlation between perceived pain intensity and suppression of brain activity in the anterior cingulate cortex when the repeated thermal sequence was applied at the lower lip. Furthermore, the response of the parahippocampal area differed in BMS patients and controls when the same repeated thermal sequence was applied at the palm. The authors' findings indicate that BMS patients show specific brain responses due to impaired function of the central and peripheral nervous systems (clinical trial registration: UMIN000015002).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mapeo Encefálico / Síndrome de Boca Ardiente Tipo de estudio: Clinical_trials / Observational_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: J Dent Res Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mapeo Encefálico / Síndrome de Boca Ardiente Tipo de estudio: Clinical_trials / Observational_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: J Dent Res Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos