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Platelet-Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.
Martande, Santosh S; Kumari, Minal; Pradeep, A R; Singh, Sonender Pal; Suke, Deepak Kumar; Guruprasad, C N.
Afiliación
  • Martande SS; Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune, Maharashtra, India.
  • Kumari M; Department of Periodontics, Vydehi Institute of Dental Sciences and Research Center, Bangalore, India.
  • Pradeep AR; Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
  • Singh SP; Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
  • Suke DK; Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
  • Guruprasad CN; Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
J Periodontol ; 87(9): 1039-46, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27294433
BACKGROUND: Platelet-rich fibrin (PRF), a second-generation platelet concentrate, and atorvastatin (ATV), a potent member of the statin group, are known to promote tissue regeneration. The current study is designed to evaluate combined efficacy of PRF and 1.2% ATV gel with open flap debridement (OFD) in treatment of intrabony defects (IBDs) in individuals with chronic periodontitis (CP). METHODS: Ninety-six individuals with single defects were categorized into three groups: 1) OFD with PRF; 2) OFD with PRF + 1.2% ATV; and 3) OFD alone. Clinical parameters: 1) site-specific plaque index; 2) modified sulcus bleeding index; 3) probing depth (PD); 4) relative clinical attachment level (rCAL); and 5) gingival marginal level were recorded at baseline before surgery and 9 months postoperatively. Percentage radiographic IBD depth reduction was evaluated at baseline and 9 months. RESULTS: PRF + 1.2% ATV and PRF alone showed significantly greater PD reduction and rCAL gain compared with OFD alone at 9 months. Furthermore, PRF + 1.2% ATV showed a similar percentage radiographic defect depth reduction (50.96% ± 4.88%) compared with PRF alone (47.91% ± 4.79%), and a greater reduction compared with OFD alone (5.54% ± 1.71%) at 9 months. CONCLUSIONS: PRF + 1.2% ATV showed similar improvements in clinical parameters with a greater percentage radiographic defect depth reduction compared with PRF alone in treatment of IBDs in individuals with CP. Thus, 1.2% ATV failed to augment the regenerative potential of PRF alone in periodontal IBDs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Crónica / Atorvastatina / Fibrina Rica en Plaquetas Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: J Periodontol Año: 2016 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Crónica / Atorvastatina / Fibrina Rica en Plaquetas Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: J Periodontol Año: 2016 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos