The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.

da Motta, L L; Ledaki, I; Purshouse, K; Haider, S; De Bastiani, M A; Baban, D; Morotti, M; Steers, G; Wigfield, S; Bridges, E; Li, J-L; Knapp, S; Ebner, D; Klamt, F; Harris, A L; McIntyre, A

da Motta, L L; Ledaki, I; Purshouse, K; Haider, S; De Bastiani, M A; Baban, D; Morotti, M; Steers, G; Wigfield, S; Bridges, E; Li, J-L; Knapp, S; Ebner, D; Klamt, F; Harris, A L; McIntyre, A.

Afiliación

da Motta LL; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Ledaki I; Department of Biochemistry/UFRGS, Porto Alegre, Brazil.
Purshouse K; CAPES Foundation, Ministry of Education of Brazil, Brasilia, Brazil.
Haider S; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
De Bastiani MA; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Baban D; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Morotti M; Department of Biochemistry/UFRGS, Porto Alegre, Brazil.
Steers G; High Throughput Genomics, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Wigfield S; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Bridges E; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Li JL; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Knapp S; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Ebner D; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Klamt F; Institute of Translational and Stratified Medicine, Plymouth University, Peninsula Schools of Medicine and Dentistry, Plymouth, UK.
Harris AL; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK.
McIntyre A; Goethe University Frankfurt, Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Campus Riedberg, Frankfurt, Germany.

Oncogene ; 36(1): 122-132, 2017 01 05.

Article en En | MEDLINE | ID: mdl-27292261

Asunto(s)

Azepinas/farmacología; Anhidrasa Carbónica IX/metabolismo; Hipoxia/metabolismo; Neovascularización Patológica; Triazoles/farmacología; Neoplasias de la Mama Triple Negativas/metabolismo; Neoplasias de la Mama Triple Negativas/patología; Animales; Anhidrasa Carbónica IX/genética; Línea Celular Tumoral; Análisis por Conglomerados; Modelos Animales de Enfermedad; Femenino; Perfilación de la Expresión Génica; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Hipoxia/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Ratones; Regiones Promotoras Genéticas; Unión Proteica; Esferoides Celulares; Transcriptoma; Neoplasias de la Mama Triple Negativas/genética; Células Tumorales Cultivadas; Factor A de Crecimiento Endotelial Vascular; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azepinas / Triazoles / Neoplasias de la Mama Triple Negativas / Anhidrasa Carbónica IX / Hipoxia / Neovascularización Patológica Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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