Your browser doesn't support javascript.
loading
Pharmacogenetic considerations in the treatment of Alzheimer's disease.
Cacabelos, Ramón; Torrellas, Clara; Teijido, Oscar; Carril, Juan Carlos.
Afiliación
  • Cacabelos R; Department of Genomic Medicine, Camilo José Cela University, Madrid, Spain.
  • Torrellas C; EuroEspes Biomedical Research Center, Institute of Medical Science and Genomic Medicine, Corunna, Spain.
  • Teijido O; EuroEspes Biomedical Research Center, Institute of Medical Science and Genomic Medicine, Corunna, Spain.
  • Carril JC; EuroEspes Biomedical Research Center, Institute of Medical Science and Genomic Medicine, Corunna, Spain.
Pharmacogenomics ; 17(9): 1041-74, 2016 06.
Article en En | MEDLINE | ID: mdl-27291247
The practical pharmacogenetics of Alzheimer's disease (AD) is circumscribed to acetylcholinesterase inhibitors (AChEIs) and memantine. However, pharmacogenetic procedures should be applied to novel strategies in AD therapeutics including: novel AChEIs and neurotransmitter regulators, anti-Aß treatments, anti-tau treatments, pleiotropic products, epigenetic drugs and combination therapies. Genes involved in the pharmacogenetic network are under the influence of the epigenetic machinery which regulates gene expression transcriptionally and post-transcriptionally, configuring the fundamentals of pharmacoepigenomics. Over 60% of AD patients present concomitant pathologies demanding additional treatments which increase the likelihood of drug-drug interactions. Lipid metabolism dysfunction is a pathogenic mechanism inherent to AD neurodegeneration. The therapeutic response to hypolipidemic compounds is influenced by the APOE and CYP genotypes. The development of novel compounds and the use of combination/multifactorial treatments require the implantation of pharmacogenomic procedures for the avoidance of ADRs and the optimization of therapeutics.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Pharmacogenomics Asunto de la revista: FARMACOLOGIA / GENETICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Pharmacogenomics Asunto de la revista: FARMACOLOGIA / GENETICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido