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A biomimetic multilayer nanofiber fabric fabricated by electrospinning and textile technology from polylactic acid and Tussah silk fibroin as a scaffold for bone tissue engineering.
Shao, Weili; He, Jianxin; Han, Qiming; Sang, Feng; Wang, Qian; Chen, Li; Cui, Shizhong; Ding, Bin.
Afiliación
  • Shao W; Key Laboratory of Advanced Textile Composites, Ministry of Education, Institute of Textile Composites, Tianjin Polytechnic University, Tianjin 300387, China; Henan provincial key laboratory of functional textile materials, Zhongyuan University of Technology, Zhengzhou 450007, China; Collaborative In
  • He J; Henan provincial key laboratory of functional textile materials, Zhongyuan University of Technology, Zhengzhou 450007, China; Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou 450007, China. Electronic address: hejianxin771117@163.com.
  • Han Q; Henan provincial key laboratory of functional textile materials, Zhongyuan University of Technology, Zhengzhou 450007, China; Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou 450007, China.
  • Sang F; Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China.
  • Wang Q; Henan provincial key laboratory of functional textile materials, Zhongyuan University of Technology, Zhengzhou 450007, China; Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou 450007, China.
  • Chen L; Key Laboratory of Advanced Textile Composites, Ministry of Education, Institute of Textile Composites, Tianjin Polytechnic University, Tianjin 300387, China.
  • Cui S; Key Laboratory of Advanced Textile Composites, Ministry of Education, Institute of Textile Composites, Tianjin Polytechnic University, Tianjin 300387, China; Henan provincial key laboratory of functional textile materials, Zhongyuan University of Technology, Zhengzhou 450007, China; Collaborative In
  • Ding B; Henan provincial key laboratory of functional textile materials, Zhongyuan University of Technology, Zhengzhou 450007, China; Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou 450007, China; State Key Laboratory for Modification of Chemical Fibers and Polymer
Mater Sci Eng C Mater Biol Appl ; 67: 599-610, 2016 Oct 01.
Article en En | MEDLINE | ID: mdl-27287159
To engineer bone tissue, a scaffold with good biological properties should be provided to approximate the hierarchical structure of collagen fibrils in natural bone. In this study, we fabricated a novel scaffold consisting of multilayer nanofiber fabrics (MLNFFs) by weaving nanofiber yarns of polylactic acid (PLA) and Tussah silk fibroin (TSF). The yarns were fabricated by electrospinning, and we found that spinnability, as well as the mechanical properties of the resulting scaffold, was determined by the ratio between polylactic acid and Tussah silk fibroin. In particular, a 9:1 mixture can be spun continuously into nanofiber yarns with narrow diameter distribution and good mechanical properties. Accordingly, woven scaffolds based on this mixture had excellent mechanical properties, with Young's modulus 417.65MPa and tensile strength 180.36MPa. For nonwoven scaffolds fabricated from the same materials, the Young's modulus and tensile strength were 2- and 4-fold lower, respectively. Woven scaffolds also supported adhesion and proliferation of mouse mesenchymal stem cells, and promoted biomineralization via alkaline phosphatase and mineral deposition. Finally, the scaffolds significantly enhanced the formation of new bone in damaged femoral condyle in rabbits. Thus, the scaffolds are potentially suitable for bone tissue engineering because of biomimetic architecture, excellent mechanical properties, and good biocompatibility.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Calcificación Fisiológica / Sustitutos de Huesos / Ingeniería de Tejidos / Andamios del Tejido / Fémur / Nanofibras / Fibroínas Límite: Animals Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Calcificación Fisiológica / Sustitutos de Huesos / Ingeniería de Tejidos / Andamios del Tejido / Fémur / Nanofibras / Fibroínas Límite: Animals Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos