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Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model.
Chin, Lee; Korpela, Elina; Kim, Anthony; Yohan, Darren; Niu, Carolyn; Wilson, Brian C; Liu, Stanley K.
Afiliación
  • Chin L; Department of Radiation Oncology, University of Toronto; Department of Physics, Ryerson University; lee.chin@sunnybrook.ca.
  • Korpela E; Department of Medical Biophysics, University of Toronto.
  • Kim A; Department of Radiation Oncology, University of Toronto.
  • Yohan D; Department of Physics, Ryerson University.
  • Niu C; Ontario Cancer Institute / Campbell Family Institute for Cancer Research.
  • Wilson BC; Department of Medical Biophysics, University of Toronto.
  • Liu SK; Department of Radiation Oncology, University of Toronto; Department of Medical Biophysics, University of Toronto.
J Vis Exp ; (111)2016 05 27.
Article en En | MEDLINE | ID: mdl-27284926
Acute skin toxicities from ionizing radiation (IR) are a common side effect from therapeutic courses of external beam radiation therapy (RT) and negatively impact patient quality of life and long term survival. Advances in the understanding of the biological pathways associated with normal tissue toxicities have allowed for the development of interventional drugs, however, current response studies are limited by a lack of quantitative metrics for assessing the severity of skin reactions. Here we present a diffuse optical spectroscopic (DOS) approach that provides quantitative optical biomarkers of skin response to radiation. We describe the instrumentation design of the DOS system as well as the inversion algorithm for extracting the optical parameters. Finally, to demonstrate clinical utility, we present representative data from a pre-clinical mouse model of radiation induced erythema and compare the results with a commonly employed visual scoring. The described DOS method offers an objective, high through-put evaluation of skin toxicity via functional response that is translatable to the clinical setting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiodermatitis / Piel / Análisis Espectral Tipo de estudio: Etiology_studies / Prognostic_studies Aspecto: Patient_preference Límite: Animals Idioma: En Revista: J Vis Exp Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiodermatitis / Piel / Análisis Espectral Tipo de estudio: Etiology_studies / Prognostic_studies Aspecto: Patient_preference Límite: Animals Idioma: En Revista: J Vis Exp Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos