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Stent Coating Integrity of Durable and Biodegradable Coated Drug Eluting Stents.
Yazdani, Saami K; Sheehy, Alexander; Pacetti, Stephen; Rittlemeyer, Brandon; Kolodgie, Frank D; Virmani, Renu.
Afiliación
  • Yazdani SK; CV Path Institute, Inc., Gaithersburg, Maryland.
  • Sheehy A; University of South Alabama, Mechanical Engineering, Mobile, Alabama.
  • Pacetti S; Abbott Vascular, Santa Clara, California.
  • Rittlemeyer B; Abbott Vascular, Santa Clara, California.
  • Kolodgie FD; University of South Alabama, Mechanical Engineering, Mobile, Alabama.
  • Virmani R; CV Path Institute, Inc., Gaithersburg, Maryland.
J Interv Cardiol ; 29(5): 483-490, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27282892
BACKGROUND: Coatings consisting of a polymer and drug are widely used in drug-eluting stents (DES) and are essential in providing programmable drug release kinetics. Among other factors, stent coating technologies can influence blood compatibility, affect acute and sub-acute healing, and potentially trigger a chronic inflammatory response. OBJECTIVE: The aim of this study was to investigate the short-term (7 and 28 days) and long-term (90 and 180 days) coating integrity of the Xience Prime Everolimus-Eluting Stent (EES), Resolute Zotarolimus-Eluting Stent (ZES), Taxus Paclitaxel-Eluting Stent (PES), and Nobori Biolimus A9-Eluting Stent (BES) in a rabbit ilio-femoral stent model. METHODS AND RESULTS: Stented arteries (n = 48) were harvested and the tissue surrounding the implanted stents digested away with an enzymatic solution. Results demonstrated that the majority of struts of EES were without any coating defects with a few struts showing minor defects. Similarly, for the ZES, most of the struts were without coating defects at all time points except at 180 days. The majority of PES demonstrated mostly webbing and uneven coating. In the BES group, the majority of strut coating showed polymer cracking. CONCLUSION: Overall, the EES and ZES had fewer coating defects than the PES and BES. Coating defects, however increase over time for the ZES, whereas the percent of coating irregularities remained constant for the EES. These results provide, for the first time, a comparison of the long-term durability of these drug-eluting stent coatings in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioplastia Coronaria con Balón / Enfermedad Coronaria / Stents Liberadores de Fármacos / Plásticos Biodegradables / Inmunosupresores / Antineoplásicos Fitogénicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Interv Cardiol Asunto de la revista: CARDIOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioplastia Coronaria con Balón / Enfermedad Coronaria / Stents Liberadores de Fármacos / Plásticos Biodegradables / Inmunosupresores / Antineoplásicos Fitogénicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Interv Cardiol Asunto de la revista: CARDIOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos