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Differential microRNA Profiles Predict Diabetic Nephropathy Progression in Taiwan.
Chien, Hung-Yu; Chen, Chang-Yi; Chiu, Yen-Hui; Lin, Yi-Chun; Li, Wan-Chun.
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  • Chien HY; 1. Department of Endocrinology & Metabolism, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan;
  • Chen CY; 2. Institute of Oral Biology and Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan;
  • Chiu YH; 3. Department of Education and Research, Taipei City Hospital, Taipei, Taiwan;
  • Lin YC; 4. Division of Endocrinology &Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan;; 5. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan;
  • Li WC; 2. Institute of Oral Biology and Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan;; 3. Department of Education and Research, Taipei City Hospital, Taipei, Taiwan;
Int J Med Sci ; 13(6): 457-65, 2016.
Article en En | MEDLINE | ID: mdl-27279796
OBJECTIVES: Diabetic nephropathy (DN) is a major leading cause of kidney failure. Recent studies showed that serological microRNAs (miRs) could be utilized as biomarkers to identify disease pathogenesis; the DN-related miRs, however, remained to be explored. METHODS: A prospective case-control study was conducted. The clinical significance of five potential miRs (miR-21, miR-29a, miR-29b, miR-29c and miR192) in type 2 Diabetes Mellitus (T2DM) patients who have existing diabetic retinopathy with differential Albumin:Creatinine Ratio (ACR) and estimated Glomerular Filtration Rate (eGFR) was performed using quantitative RT-PCR analysis. The subjects with diabetic retinopathy enrolled in Taipei City Hospital, Taiwan, were classified into groups of normal albuminuria (ACR<30mg/g; N=12); microalbuminuria (30mg/g300mg/g; N=21) as well as 18 low-eGFR (eGFR<60ml/min) and 32 high-eGFR (eGFR>60ml/min). The level of serum miRs was statistically correlated with age, Glucose AC, ACR, eGFR and DN progression. RESULTS: The levels of miR-21, miR-29a and miR-192 were significantly enriched in the overt proteinuria group compared with microalbuminuria and/or overt proteinuria groups. It was shown that only miR-21 level was significantly up-regulated in low-eGFR group compared with high-eGFR patients. Interestingly, Pearson's correlation coefficient analysis demonstrated that DN progressors showed significantly greater levels of miR-21, miR-29a, miR-29b and miR-29c in comparison with non-progressors implying the clinical potential of DN associated miRs in monitoring and preventing disease advancement. CONCLUSION: Our findings showed that miR-21, miR-29a/b/c and miR-192 could reflect DN pathogenesis and serve as biomarkers during DN progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Nefropatías Diabéticas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2016 Tipo del documento: Article Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Nefropatías Diabéticas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2016 Tipo del documento: Article Pais de publicación: Australia