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Outcome in dogs with advanced (stage 3b) anal sac gland carcinoma treated with surgery or hypofractionated radiation therapy.
Meier, V; Polton, G; Cancedda, S; Roos, M; Laganga, P; Emmerson, T; Rohrer Bley, C.
Afiliación
  • Meier V; Division of Radiation Oncology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland.
  • Polton G; North Downs Specialist Referrals, Surrey, UK.
  • Cancedda S; Centro Oncologico Veterinario, Sasso Marconi, Italy.
  • Roos M; Department of Biostatistics, Epidemiology Biostatistics and Prevention Institute, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
  • Laganga P; Centro Oncologico Veterinario, Sasso Marconi, Italy.
  • Emmerson T; North Downs Specialist Referrals, Surrey, UK.
  • Rohrer Bley C; Division of Radiation Oncology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland.
Vet Comp Oncol ; 15(3): 1073-1086, 2017 Sep.
Article en En | MEDLINE | ID: mdl-27278807
Stage 3b anal sac gland carcinoma (ASGC) can be life-threatening. A surgical approach is not always possible or may be declined. Dogs with stage 3b ASGC treated with surgery or conformal radiation therapy (RT) with 8 × 3.8 Gy (total dose 30.4 Gy, over 2.5 weeks) were retrospectively evaluated. Patient characteristics, median progression-free interval (PFI) and median survival time (MST) were compared. Twenty-eight dogs were included; 15 underwent surgery, 13 underwent RT. At the time of presentation, 21% showed life-threatening obstipation and 25% showed hypercalcaemia. PFI and MST for surgery cases were 159 days (95% CI: 135-184 days) and 182 days (95% CI: 146-218 days), both significantly lower than for RT cases with 347 days (95% CI: 240-454 days) and 447 days (95% CI: 222-672 days), (P = 0.01, P = 0.019). Surgery as well as RT led to a fast relief of symptoms. PFI and survival of surgical patients were significantly inferior to that of a comparable patient group treated with conformal hypofractionated RT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Perros / Neoplasias de las Glándulas Anales / Sacos Anales Límite: Animals Idioma: En Revista: Vet Comp Oncol Asunto de la revista: MEDICINA VETERINARIA / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Perros / Neoplasias de las Glándulas Anales / Sacos Anales Límite: Animals Idioma: En Revista: Vet Comp Oncol Asunto de la revista: MEDICINA VETERINARIA / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido