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Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents.
Szabó, Johanna; Pataki, Zoltán; Wölfling, János; Schneider, Gyula; Bózsity, Noémi; Minorics, Renáta; Zupkó, István; Mernyák, Erzsébet.
Afiliación
  • Szabó J; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Pataki Z; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Wölfling J; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Schneider G; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Bózsity N; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
  • Minorics R; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
  • Zupkó I; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary. Electronic address: zupko@pharm.u-szeged.hu.
  • Mernyák E; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary. Electronic address: bobe@chem.u-szeged.hu.
Steroids ; 113: 14-21, 2016 09.
Article en En | MEDLINE | ID: mdl-27263437
13α-Estrone derivatives containing various substituents on C-3 and C-17 were synthesized, and evaluated by means of MTT assays for in vitro antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A2780 and A431). Compounds with N-benzyltriazolylmethoxy moieties on C-3 proved to be more potent than their 3-hydroxy or 3-ether counterparts. Some triazoles exerted substantial cytostatic effects against particular tumor cell lines, with submicromolar IC50 values.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrona / Antineoplásicos Límite: Humans Idioma: En Revista: Steroids Año: 2016 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrona / Antineoplásicos Límite: Humans Idioma: En Revista: Steroids Año: 2016 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos