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High shear stress relates to intraplaque haemorrhage in asymptomatic carotid plaques.
Tuenter, A; Selwaness, M; Arias Lorza, A; Schuurbiers, J C H; Speelman, L; Cibis, M; van der Lugt, A; de Bruijne, M; van der Steen, A F W; Franco, O H; Vernooij, M W; Wentzel, J J.
Afiliación
  • Tuenter A; Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands; Netherlands Institute for Health Sciences, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
  • Selwaness M; Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
  • Arias Lorza A; Biomedical Imaging Group Rotterdam, Departments of Medical Informatics, Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Schuurbiers JCH; Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands.
  • Speelman L; Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands.
  • Cibis M; Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands.
  • van der Lugt A; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
  • de Bruijne M; Biomedical Imaging Group Rotterdam, Departments of Medical Informatics, Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands; Department of Computer Science, University of Copenhagen, Denmark.
  • van der Steen AFW; Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands.
  • Franco OH; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Vernooij MW; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
  • Wentzel JJ; Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands. Electronic address: j.wentzel@erasmusmc.nl.
Atherosclerosis ; 251: 348-354, 2016 08.
Article en En | MEDLINE | ID: mdl-27263078
BACKGROUND AND AIMS: Carotid artery plaques with vulnerable plaque components are related to a higher risk of cerebrovascular accidents. It is unknown which factors drive vulnerable plaque development. Shear stress, the frictional force of blood at the vessel wall, is known to influence plaque formation. We evaluated the association between shear stress and plaque components (intraplaque haemorrhage (IPH), lipid rich necrotic core (LRNC) and/or calcifications) in relatively small carotid artery plaques in asymptomatic persons. METHODS: Participants (n = 74) from the population-based Rotterdam Study, all with carotid atherosclerosis assessed on ultrasound, underwent carotid MRI. Multiple MRI sequences were used to evaluate the presence of IPH, LRNC and/or calcifications in plaques in the carotid arteries. Images were automatically segmented for lumen and outer wall to obtain a 3D reconstruction of the carotid bifurcation. These reconstructions were used to calculate minimum, mean and maximum shear stresses by applying computational fluid dynamics with subject-specific inflow conditions. Associations between shear stress measures and plaque composition were studied using generalized estimating equations analysis, adjusting for age, sex and carotid wall thickness. RESULTS: The study group consisted of 93 atherosclerotic carotid arteries of 74 participants. In plaques with higher maximum shear stresses, IPH was more often present (OR per unit increase in maximum shear stress (log transformed) = 12.14; p = 0.001). Higher maximum shear stress was also significantly associated with the presence of calcifications (OR = 4.28; p = 0.015). CONCLUSIONS: Higher maximum shear stress is associated with intraplaque haemorrhage and calcifications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Carótidas / Resistencia al Corte / Placa Aterosclerótica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Atherosclerosis Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Carótidas / Resistencia al Corte / Placa Aterosclerótica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Atherosclerosis Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Irlanda