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Partial ileal bypass affords protection from onset of type 2 diabetes.
Buchwald, Henry; Oien, Danette M; Schieber, Decel J; Bantle, John P; Connett, John E.
Afiliación
  • Buchwald H; Department of Surgery, the Medical School, University of Minnesota, Minneapolis, Minnesota. Electronic address: buchw001@umn.edu.
  • Oien DM; Department of Surgery, the Medical School, University of Minnesota, Minneapolis, Minnesota.
  • Schieber DJ; Department of Surgery, the Medical School, University of Minnesota, Minneapolis, Minnesota.
  • Bantle JP; Department of Medicine, the Medical School, University of Minnesota, Minneapolis, Minnesota.
  • Connett JE; School of Public Health, the Medical School, University of Minnesota, Minneapolis, Minnesota.
Surg Obes Relat Dis ; 13(1): 45-51, 2017 Jan.
Article en En | MEDLINE | ID: mdl-27262236
BACKGROUND: Partial ileal bypass (PIB) in the National Institutes of Health-sponsored Program on the Surgical Control of the Hyperlipidemias (POSCH) randomized controlled trial was found to reduce plasma cholesterol, in particular low density lipoprotein cholesterol, with concomitant retardation of atherosclerotic cardiovascular disease and increased life expectancy. Glucagon-like peptide-1, related to amelioration of type 2 diabetes, is increased over 5-fold after PIB. We hypothesized that PIB, in addition to its action on cholesterol metabolism, may also prevent type 2 diabetes. METHODS: We surveyed by telephone inquiry of former POSCH patients the 30+year posttrial incidence of type 2 diabetes or prediabetes, the presence of which was a trial exclusion criteria. We were able to contact 17.4% (n = 838) of the original POSCH population. RESULTS: Of 66 control responders, 17 contracted type 2 diabetes (25.8%); of 80 PIB responders, 8 contracted type 2 diabetes (10%). The difference between groups was significant (P = .015 by Fisher exact test) with an odds ratio of .320 for the PIB group and an over 2-fold (2.6) increase in the incidence of type 2 diabetes in the controls. Including borderline type 2 diabetes (prediabetic) patients, these values were 22 of 66 controls (33.3%) and 10 of 80 PIB patients (12.5%), with an odds ratio of .286 and a P<.004, and again an over 2-fold (2.7) increase in the incidence of type 2 diabetes in the control patients. CONCLUSION: PIB appears to afford partial protection from the onset of type 2 diabetes for over 30 years.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derivación Gástrica / Diabetes Mellitus Tipo 2 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Surg Obes Relat Dis Asunto de la revista: METABOLISMO Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derivación Gástrica / Diabetes Mellitus Tipo 2 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Surg Obes Relat Dis Asunto de la revista: METABOLISMO Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos