Problems of Glioblastoma Multiforme Drug Resistance.
Biochemistry (Mosc)
; 81(2): 91-100, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-27260389
Glioblastoma multiforme (GBL) is the most common and aggressive brain neoplasm. A standard therapeutic approach for GBL involves combination therapy consisting of surgery, radiotherapy, and chemotherapy. The latter is based on temozolomide (TMZ). However, even by applying such a radical treatment strategy, the mean patient survival time is only 14.6 months. Here we review the molecular mechanisms underlying the resistance of GBL cells to TMZ including genetic and epigenetic mechanisms. Present data regarding a role for genes and proteins MGMT, IDH1/2, YB-1, MELK, MVP/LRP, MDR1 (ABCB1), and genes encoding other ABC transporters as well as Akt3 kinase in developing resistance of GBL to TMZ are discussed. Some epigenetic regulators of resistance to TMZ such as microRNA and EZH2 are reviewed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Glioblastoma
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Resistencia a Antineoplásicos
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Antineoplásicos Alquilantes
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Dacarbazina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochemistry (Mosc)
Año:
2016
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Estados Unidos