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Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.
Corrochano, Luis M; Kuo, Alan; Marcet-Houben, Marina; Polaino, Silvia; Salamov, Asaf; Villalobos-Escobedo, José M; Grimwood, Jane; Álvarez, M Isabel; Avalos, Javier; Bauer, Diane; Benito, Ernesto P; Benoit, Isabelle; Burger, Gertraud; Camino, Lola P; Cánovas, David; Cerdá-Olmedo, Enrique; Cheng, Jan-Fang; Domínguez, Angel; Eliás, Marek; Eslava, Arturo P; Glaser, Fabian; Gutiérrez, Gabriel; Heitman, Joseph; Henrissat, Bernard; Iturriaga, Enrique A; Lang, B Franz; Lavín, José L; Lee, Soo Chan; Li, Wenjun; Lindquist, Erika; López-García, Sergio; Luque, Eva M; Marcos, Ana T; Martin, Joel; McCluskey, Kevin; Medina, Humberto R; Miralles-Durán, Alejandro; Miyazaki, Atsushi; Muñoz-Torres, Elisa; Oguiza, José A; Ohm, Robin A; Olmedo, María; Orejas, Margarita; Ortiz-Castellanos, Lucila; Pisabarro, Antonio G; Rodríguez-Romero, Julio; Ruiz-Herrera, José; Ruiz-Vázquez, Rosa; Sanz, Catalina; Schackwitz, Wendy.
Afiliación
  • Corrochano LM; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain. Electronic address: corrochano@us.es.
  • Kuo A; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • Marcet-Houben M; Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain.
  • Polaino S; School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA.
  • Salamov A; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • Villalobos-Escobedo JM; Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.
  • Grimwood J; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.
  • Álvarez MI; Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
  • Avalos J; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Bauer D; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • Benito EP; Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.
  • Benoit I; CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
  • Burger G; Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.
  • Camino LP; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Cánovas D; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Cerdá-Olmedo E; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Cheng JF; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • Domínguez A; Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
  • Eliás M; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic.
  • Eslava AP; Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
  • Glaser F; Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
  • Gutiérrez G; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Heitman J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
  • Henrissat B; Centre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
  • Iturriaga EA; Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
  • Lang BF; Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.
  • Lavín JL; Genome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain.
  • Lee SC; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
  • Li W; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
  • Lindquist E; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • López-García S; Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.
  • Luque EM; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Marcos AT; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Martin J; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • McCluskey K; Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA.
  • Medina HR; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Miralles-Durán A; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Miyazaki A; Department of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan.
  • Muñoz-Torres E; Departamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avenida Campus Miguel de Unamuno, 37007 Salamanca, Spain.
  • Oguiza JA; Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
  • Ohm RA; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • Olmedo M; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Orejas M; Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avenida Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain.
  • Ortiz-Castellanos L; Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.
  • Pisabarro AG; Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
  • Rodríguez-Romero J; Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
  • Ruiz-Herrera J; Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.
  • Ruiz-Vázquez R; Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.
  • Sanz C; Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
  • Schackwitz W; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Curr Biol ; 26(12): 1577-1584, 2016 06 20.
Article en En | MEDLINE | ID: mdl-27238284
Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Phycomyces / Transducción de Señal / Genoma Fúngico / Evolución Molecular / Duplicación de Gen / Mucor Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Phycomyces / Transducción de Señal / Genoma Fúngico / Evolución Molecular / Duplicación de Gen / Mucor Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido