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Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors.
Yoon, Y E; Cho, Y I; Kim, S Y; Lee, H H; Huh, K H; Kim, Y S; Han, W K.
Afiliación
  • Yoon YE; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Cho YI; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea.
  • Kim SY; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Lee HH; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Huh KH; Department of Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
  • Kim YS; Department of Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
  • Han WK; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address: hanwk@yuhs.ac.
Transplant Proc ; 48(3): 738-41, 2016 Apr.
Article en En | MEDLINE | ID: mdl-27234725
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL levels for renal function after living donor nephrectomy. METHODS: Between July 2013 and May 2014, 112 donors underwent live donor nephrectomy at our institution. Donor plasma NGAL levels were measured perioperatively for 6 months. The relationship between perioperative plasma NGAL and recovery of renal function was analyzed. Renal function was estimated with the Modification of Diet in Renal Disease formula. RESULTS: Mean preoperative NGAL was 62.1 ± 29.5 ng/mL. Plasma NGAL was most elevated 1 week postoperatively (218 ± 95.5 ng/mL), and stabilized after 1 month (122.9 ± 45.3 ng/mL). Preoperative plasma NGAL was not correlated with donor age or preoperative estimated glomerular filtration rates (eGFR), but was negatively correlated with 6-month eGFR (r = -0.458, P < .001). During the observation period, plasma NGAL at 1 week was most correlated with 6-month eGFR (r = -0.554, P < .001). An ROC curve analysis showed that age, preoperative eGFR, and 1-week postoperative plasma NGAL were highly predictive of developing of chronic kidney disease (CKD), defined as eGFR <60 mL/min/1.73 m(2), 6 months postoperatively (AUC = 0.91, P < .001). One-week postoperative plasma NGAL was also independently associated with CKD risk at 6 months (odds ratio: 1.13 for each 10 ng/mL increase, P = .013). CONCLUSION: Plasma NGAL becomes elevated after kidney donation and can provide information about acute kidney injury during the compensatory hyperfiltration period. Donors with increased perioperative plasma NGAL require close observation because their possibility of developing CKD after donation may be greater.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Donadores Vivos / Recuperación de la Función / Lipocalina 2 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Transplant Proc Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Donadores Vivos / Recuperación de la Función / Lipocalina 2 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Transplant Proc Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos