Your browser doesn't support javascript.
loading
Abdominal Aortic Calcification in Living Kidney Donors.
Yoon, Y E; Han, W K; Lee, H H; Chang, M-Y; Huh, K H; Jung, D C; Kim, Y S; Oh, Y T.
Afiliación
  • Yoon YE; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Han WK; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Lee HH; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Chang MY; Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Huh KH; Department of Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
  • Jung DC; Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Kim YS; Department of Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
  • Oh YT; Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address: OYTAIK@yuhs.ac.
Transplant Proc ; 48(3): 720-4, 2016 Apr.
Article en En | MEDLINE | ID: mdl-27234721
OBJECTIVE: This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. METHODS: Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. RESULTS: The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P < .001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P = .035). Donors with AAC were more likely to have glomerulosclerosis (50.0% vs 29.1%; P = .022), tubular atrophy (62.5% vs 33.1%; P = .002), and a higher nephrosclerosis score (P = .002). CONCLUSIONS: Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta Abdominal / Donadores Vivos / Recolección de Tejidos y Órganos / Calcificación Vascular / Nefrectomía Tipo de estudio: Etiology_studies / Evaluation_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta Abdominal / Donadores Vivos / Recolección de Tejidos y Órganos / Calcificación Vascular / Nefrectomía Tipo de estudio: Etiology_studies / Evaluation_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos