Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives.
J Clin Pharmacol
; 29(3): 257-60, 1989 Mar.
Article
en En
| MEDLINE
| ID: mdl-2723113
Thirteen women chronically using low-dose estrogen-containing oral contraceptives (50 micrograms or less of ethinyl estradiol or its equivalent for a minimum of 3 months) and 12 age-matched drug-free control women received a single 25 mg oral dose of doxylamine succinate in the fasting state. Ten women taking oral contraceptives and ten controls received a single 50 mg oral dose of diphenhydramine hydrochloride. Multiple plasma samples drawn during 30 hours following the dose of doxylamine, and 12 hours after diphenhydramine dosage, were analyzed by gas chromatography using nitrogen-phosphorus detection. Mean pharmacokinetic variables for doxylamine in control and oral contraceptive groups were: peak plasma concentration, 103 vs 100 ng/ml; time of peak, 2.40 vs 1.87 hours after dosage, elimination half-life, 10.1 vs 10.2 hours; and total clearance, 3.70 vs 3.88 ml/min/kg. Mean pharmacokinetic variables for diphenhydramine in control and oral contraceptive groups were: peak plasma concentration, 63.7 vs 73.8 ng/ml; time of peak, 2.7 vs 2.2 hours after dosage; elimination half-life, 6.0 vs 5.1 hours; and total clearance, 21.8 vs 25.5 ml/min/kg. None of these differences were statistically significant. Thus, low-dose estrogen-containing oral contraceptives do not significantly influence the pharmacokinetics of the antihistamines doxylamine or diphenhydramine.
Palabras clave
Age Distribution; Age Factors; Biology; Body Weight; Contraception; Contraceptive Methods; Control Groups; Data Analysis; Data Collection; Demographic Factors; Drug Interactions; Drugs--pharmacodynamics; Examinations And Diagnoses; Family Planning; Laboratory Examinations And Diagnoses; Oral Contraceptives; Oral Contraceptives, Low-dose; Physiology; Population; Population Characteristics; Research Methodology; Treatment
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Difenhidramina
/
Doxilamina
/
Etinilestradiol
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Clin Pharmacol
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Reino Unido