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Cytogenetic profiles of 2806 patients with acute myeloid leukemia-a retrospective multicenter nationwide study.
Byun, Ja Min; Kim, Young Jin; Yoon, Hwi-Joong; Kim, Si-Young; Kim, Hee-Je; Yoon, Jaeho; Min, Yoo Hong; Cheong, Jun-Won; Park, Jinny; Lee, Jae Hoon; Hong, Dae Sik; Park, Seong Kyu; Kim, Hyeoung-Joon; Ahn, Jae-Sook; Shin, Ho-Jin; Chung, Joo Seop; Lee, Won Sik; Lee, Sang Min; Park, Yong; Kim, Byung Soo; Lee, Je-Hwan; Lee, Kyoo-Hyung; Jung, Chul Won; Jang, Jun Ho; Min, Woo-Sung; Park, Tae Sung.
Afiliación
  • Byun JM; Department of Medicine, Kyung Hee University Graduate School, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea.
  • Kim YJ; Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea.
  • Yoon HJ; Department of Internal Medicine, School of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea.
  • Kim SY; Department of Internal Medicine, School of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea.
  • Kim HJ; Department of Internal Medicine, Cancer Research Institute, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea.
  • Yoon J; Department of Internal Medicine, Cancer Research Institute, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea.
  • Min YH; Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea.
  • Cheong JW; Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea.
  • Park J; Department of Internal Medicine, Gachon University Gil Medical Center, Seongnam-si, Republic of Korea.
  • Lee JH; Department of Internal Medicine, Gachon University Gil Medical Center, Seongnam-si, Republic of Korea.
  • Hong DS; Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
  • Park SK; Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
  • Kim HJ; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea.
  • Ahn JS; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea.
  • Shin HJ; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
  • Chung JS; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
  • Lee WS; Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • Lee SM; Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • Park Y; Department of Internal Medicine, Korea University School of Medicine Anam Hospital, Seoul, Republic of Korea.
  • Kim BS; Department of Internal Medicine, Korea University School of Medicine Anam Hospital, Seoul, Republic of Korea.
  • Lee JH; Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Lee KH; Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Jung CW; Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Jang JH; Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Min WS; Department of Internal Medicine, Cancer Research Institute, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea. wsmin@catholic.ac.kr.
  • Park TS; Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea. 153jesus@hanmail.net.
Ann Hematol ; 95(8): 1223-32, 2016 Aug.
Article en En | MEDLINE | ID: mdl-27230620
The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively reviewed medical records of 2806 AML patients diagnosed at 11 tertiary teaching hospitals in Korea between January 2007 and December 2011. The most common recurrent chromosomal abnormality was t(8;21) (8.8 %, 238/2717), but t(15;17) showed an almost same number (8.6 %,235/2717). Among de novo AML, the most frequent aberrations were t(15;17), observed in 229 (10.7 %). The most common French-American-British (FAB) classification type was M2 (32.2 %), and recurrent cytogenetic abnormalities correlated with the FAB subtypes. Among 283 secondary AML cases, myelodysplastic syndrome was the most common predisposing factor. About 67.1 % of the secondary AML cases were associated with chromosomal aberrations, and chromosome 7 abnormalities (n = 45, 15.9 %) were most common. The incidence of FLT3 internal tandem duplication mutation was relatively low at 15 %. Our study reports certain similarities and differences in comparison to previous reports. Such discrepancies call for extensive epidemiological studies to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Leucemia Mieloide / Análisis Citogenético / Mutación Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Leucemia Mieloide / Análisis Citogenético / Mutación Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Alemania