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Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with Mycoplasma pneumoniae infection.
Yuan, Zhe-Feng; Shen, Jue; Mao, Shan-Shan; Yu, Yong-Lin; Xu, Lu; Jiang, Pei-Fang; Gao, Feng; Xia, Zhe-Zhi.
Afiliación
  • Yuan ZF; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China.
  • Shen J; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China. shenjue1982@163.com.
  • Mao SS; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China.
  • Yu YL; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China.
  • Xu L; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China.
  • Jiang PF; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China.
  • Gao F; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China.
  • Xia ZZ; Department of neurology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, Zhejiang Province, China.
BMC Infect Dis ; 16: 230, 2016 05 26.
Article en En | MEDLINE | ID: mdl-27230114
BACKGROUND: Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by transient mild symptoms of encephalopathy and a reversible lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). It is often triggered by infection. The common pathogens of MERS are viruses, especially influenza virus. However, Mycoplasma pneumoniae (M.pneumoniae) are relatively rare pathogens for MERS. CASE PRESENTATION: Here we report two paediatric cases of M.pneumoniae infection-induced MERS. The diagnosis of M.pneumoniae infection was established based on polymerase chain reaction (PCR) and specific serum antibodies (IgM). Both of the two patients presented with mild encephalopathy manifestations and recovered completely within a few days. The initial MRI showed a lesion in the central portion of the splenium of the corpus callosum, which completely resolved on the seventh and eighth day after admission for case 1 and case 2. Lumbar puncture was performed in both patients, which revealed no pleocytosis. In case 1, the patient had hyponatremia, peripheral facial nerve paralysis, and rash. To the best of our knowledge, it is the first MERS case associated with peripheral nerve damage. In case 2, interleukin-6(IL-6) was moderately increased in the cerebrospinal fluid (CSF). It suggested that IL-6 may play a role in the pathogenesis of M.pneumoniae-induced MERS. CONCLUSION: Our study enriches the available information on the pathogens of MERS and provides valuable data for better understanding of this syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Calloso / Encefalitis / Infecciones por Mycoplasma / Mycoplasma pneumoniae Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Child / Humans / Male Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Calloso / Encefalitis / Infecciones por Mycoplasma / Mycoplasma pneumoniae Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Child / Humans / Male Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido