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Evaluation of proinflammatory cytokine and neopterin levels in women with papillary thyroid carcinoma.
Beksac, Kemal; Sonmez, Cigdem; Cetin, Bahadir; Kismali, Gorkem; Sel, Tevhide; Tuncer, Yildirim; Kosova, Funda.
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  • Beksac K; Department of General Surgery, Ankara Oncology Hospital, Ankara - Turkey.
  • Sonmez C; Department of Biochemistry, Ankara Oncology Hospital, Ankara - Turkey.
  • Cetin B; Department of General Surgery, Ankara Oncology Hospital, Ankara - Turkey.
  • Kismali G; Department of Biochemistry, Ankara University Faculty of Veterinary Medicine, Ankara - Turkey.
  • Sel T; Department of Biochemistry, Ankara University Faculty of Veterinary Medicine, Ankara - Turkey.
  • Tuncer Y; Department of General Surgery, Ankara Oncology Hospital, Ankara - Turkey.
  • Kosova F; Department of Biochemistry, Celal Bayar University, Manisa - Turkey.
Int J Biol Markers ; 31(4): e446-e450, 2016 Dec 23.
Article en En | MEDLINE | ID: mdl-27229482
INTRODUCTION: Papillary thyroid cancer is a disease that has been associated with chronic inflammation. The purpose of this study is to measure the production of the proinflammatory cytokines IL-1ß, IL-6 and IL-8 and neopterin, which is a novel biomarker for cellular immune response in papillary thyroid cancer. MATERIALS AND METHODS: The serum IL-1ß, IL-6, IL-8 and neopterin values of 31 papillary thyroid cancer patients undergoing bilateral total thyroidectomy were measured before and 20 days after surgery. The values were compared with those of 39 healthy controls. RESULTS: Serum IL-1ß levels were similar across groups. IL-6 (p<0.001), IL-8 (p = 0.015) and neopterin levels (p = 0.002) were higher in presurgical samples and returned to normal following surgery. CONCLUSIONS: The proinflammatory cytokines IL-6 and IL-8, but not IL-1ß, were produced in greater amounts in papillary thyroid cancer. Serum neopterin seems to be a valid biological marker supporting the presence of papillary thyroid cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Carcinoma / Interleucinas / Neopterin Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: Int J Biol Markers Asunto de la revista: BIOQUIMICA / NEOPLASIAS Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Carcinoma / Interleucinas / Neopterin Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: Int J Biol Markers Asunto de la revista: BIOQUIMICA / NEOPLASIAS Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos