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Clinicopathologic Correlation of Lens Epithelial Metaplasia and Late Intraocular Lens Dislocation After Repair of Retinal Detachment.
Heng, Ling Zhi; Sandhu, Ranjit; Snead, D R J; Poulson, Arabella; Snead, Martin.
Afiliación
  • Heng LZ; Vitreoretinal Service, Addenbrooke's Hospital, Cambridge University Hospital, National Health Service Foundation Trust, Cambridge, England.
  • Sandhu R; Department of Ophthalmology, Luton and Dunstable Hospital National Health Service Trust, Bedfordshire, England.
  • Snead DR; Department of Pathology, University Hospitals of Coventry, Coventry, England.
  • Poulson A; Vitreoretinal Service, Addenbrooke's Hospital, Cambridge University Hospital, National Health Service Foundation Trust, Cambridge, England.
  • Snead M; Vitreoretinal Service, Addenbrooke's Hospital, Cambridge University Hospital, National Health Service Foundation Trust, Cambridge, England.
JAMA Ophthalmol ; 134(7): 827-30, 2016 Jul 01.
Article en En | MEDLINE | ID: mdl-27227434
IMPORTANCE: In-the-bag intraocular lens dislocation is an uncommon but serious complication of cataract surgery in patients with previous repair of retinal detachment. The causative mechanism is currently unknown. We report histologic findings from a retrospective case series from 1993 to 2010 and suggest a possible mechanism to explain this association. OBSERVATIONS: Clinical characteristics of 8 patients presenting with in-the-bag intraocular lens dislocation after repair of retinal detachment were evaluated. Explanted capsular bags from 3 of these patients were compared with pathologic changes of crystalline lenses associated with retinal detachment. Histologic examination of the explanted capsular bags revealed a paucicellular membrane that covered the concertina-like folded surface of the lens capsule. The lens capsule was devoid of epithelial cell nuclei and showed excessive thickening with the presence of spindle-shaped cells, such as fibroblasts. Collagen fibers were noted in the extracellular matrix. CONCLUSIONS AND RELEVANCE: Previous studies of crystalline lens pathologic findings associated with retinal detachment have shown changes in the epithelium with migration and subsequent metaplasia of epithelial cells, resulting in excessive thickening of the anterior capsule with a layer of fibrous tissue. In this retrospective series, similar histologic findings were seen, suggesting that zonular dehiscence and lens dislocation may result from progressive capsular contraction secondary to retinal detachment-induced lens epithelial metaplasia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Desprendimiento de Retina / Células Epiteliales / Migracion de Implante de Lente Artificial / Cápsula del Cristalino Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: JAMA Ophthalmol Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Desprendimiento de Retina / Células Epiteliales / Migracion de Implante de Lente Artificial / Cápsula del Cristalino Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: JAMA Ophthalmol Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos