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Heteronuclear Ir(III)-Ln(III) Luminescent Complexes: Small-Molecule Probes for Dual Modal Imaging and Oxygen Sensing.
Jana, Atanu; Crowston, Bethany J; Shewring, Jonathan R; McKenzie, Luke K; Bryant, Helen E; Botchway, Stanley W; Ward, Andrew D; Amoroso, Angelo J; Baggaley, Elizabeth; Ward, Michael D.
Afiliación
  • Jana A; Department of Chemistry, University of Sheffield , Sheffield, S3 7HF, United Kingdom.
  • Crowston BJ; Department of Chemistry, University of Sheffield , Sheffield, S3 7HF, United Kingdom.
  • Shewring JR; Department of Chemistry, University of Sheffield , Sheffield, S3 7HF, United Kingdom.
  • McKenzie LK; Department of Chemistry, University of Sheffield , Sheffield, S3 7HF, United Kingdom.
  • Bryant HE; Department of Oncology & Metabolism, University of Sheffield , Sheffield, S10 2RX, United Kingdom.
  • Botchway SW; Department of Oncology & Metabolism, University of Sheffield , Sheffield, S10 2RX, United Kingdom.
  • Ward AD; Rutherford Appleton Laboratory, STFC, Research Complex at Harwell, Harwell Science and Innovation Campus , Didcot, OX11 0FA, United Kingdom.
  • Amoroso AJ; Rutherford Appleton Laboratory, STFC, Research Complex at Harwell, Harwell Science and Innovation Campus , Didcot, OX11 0FA, United Kingdom.
  • Baggaley E; School of Chemistry, Cardiff University , Main Building, Park Place, Cardiff CF10 3AT, United Kingdom.
  • Ward MD; Department of Chemistry, University of Sheffield , Sheffield, S3 7HF, United Kingdom.
Inorg Chem ; 55(11): 5623-33, 2016 Jun 06.
Article en En | MEDLINE | ID: mdl-27219675
Luminescent, mixed metal d-f complexes have the potential to be used for dual (magnetic resonance imaging (MRI) and luminescence) in vivo imaging. Here, we present dinuclear and trinuclear d-f complexes, comprising a rigid framework linking a luminescent Ir center to one (Ir·Ln) or two (Ir·Ln2) lanthanide metal centers (where Ln = Eu(III) and Gd(III), respectively). A range of physical, spectroscopic, and imaging-based properties including relaxivity arising from the Gd(III) units and the occurrence of Ir(III) → Eu(III) photoinduced energy-transfer are presented. The rigidity imposed by the ligand facilitates high relaxivities for the Gd(III) complexes, while the luminescence from the Ir(III) and Eu(III) centers provide luminescence imaging capabilities. Dinuclear (Ir·Ln) complexes performed best in cellular studies, exhibiting good solubility in aqueous solutions, low toxicity after 4 and 18 h, respectively, and punctate lysosomal staining. We also demonstrate the first example of oxygen sensing in fixed cells using the dyad Ir·Gd, via two-photon phosphorescence lifetime imaging (PLIM).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Sondas Moleculares / Iridio / Lantano Límite: Humans Idioma: En Revista: Inorg Chem Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Sondas Moleculares / Iridio / Lantano Límite: Humans Idioma: En Revista: Inorg Chem Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos