Your browser doesn't support javascript.
loading
Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses.
Müller, Marcel A; Devignot, Stéphanie; Lattwein, Erik; Corman, Victor Max; Maganga, Gaël D; Gloza-Rausch, Florian; Binger, Tabea; Vallo, Peter; Emmerich, Petra; Cottontail, Veronika M; Tschapka, Marco; Oppong, Samuel; Drexler, Jan Felix; Weber, Friedemann; Leroy, Eric M; Drosten, Christian.
Afiliación
  • Müller MA; University of Bonn Medical Centre, Bonn, Germany.
  • Devignot S; University of Marburg, Institute for Virology, Marburg, Germany.
  • Lattwein E; Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany.
  • Corman VM; EUROIMMUN AG, Lübeck, Germany.
  • Maganga GD; University of Bonn Medical Centre, Bonn, Germany.
  • Gloza-Rausch F; German Centre for Infection Research (DZIF)-Partner Site Bonn-Cologne, Bonn, Germany.
  • Binger T; Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
  • Vallo P; Noctalis, Bad Segeberg, Germany.
  • Emmerich P; University of Bonn Medical Centre, Bonn, Germany.
  • Cottontail VM; Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
  • Tschapka M; University of Ulm, Ulm, Germany.
  • Oppong S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  • Drexler JF; University of Ulm, Ulm, Germany.
  • Weber F; Smithsonian Tropical Research Institute, Balboa, Panama.
  • Leroy EM; University of Ulm, Ulm, Germany.
  • Drosten C; Smithsonian Tropical Research Institute, Balboa, Panama.
Sci Rep ; 6: 26637, 2016 05 24.
Article en En | MEDLINE | ID: mdl-27217069
Crimean Congo hemorrhagic fever virus (CCHFV) is a highly virulent tick-borne pathogen that causes hemorrhagic fever in humans. The geographic range of human CCHF cases largely reflects the presence of ticks. However, highly similar CCHFV lineages occur in geographically distant regions. Tick-infested migratory birds have been suggested, but not confirmed, to contribute to the dispersal. Bats have recently been shown to carry nairoviruses distinct from CCHFV. In order to assess the presence of CCHFV in a wide range of bat species over a wide geographic range, we analyzed 1,135 sera from 16 different bat species collected in Congo, Gabon, Ghana, Germany, and Panama. Using a CCHFV glycoprotein-based indirect immunofluorescence test (IIFT), we identified reactive antibodies in 10.0% (114/1,135) of tested bats, pertaining to 12/16 tested species. Depending on the species, 3.6%-42.9% of cave-dwelling bats and 0.6%-7.1% of foliage-living bats were seropositive (two-tailed t-test, p = 0.0447 cave versus foliage). 11/30 IIFT-reactive sera from 10 different African bat species had neutralizing activity in a virus-like particle assay. Neutralization of full CCHFV was confirmed in 5 of 7 sera. Widespread infection of cave-dwelling bats may indicate a role for bats in the life cycle and geographic dispersal of CCHFV.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quirópteros / Virus de la Fiebre Hemorrágica de Crimea-Congo / Fiebre Hemorrágica de Crimea Límite: Animals / Humans País/Región como asunto: Africa / America central / Europa / Panama Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quirópteros / Virus de la Fiebre Hemorrágica de Crimea-Congo / Fiebre Hemorrágica de Crimea Límite: Animals / Humans País/Región como asunto: Africa / America central / Europa / Panama Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido