Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-ß pathways.

Liu, Jiao; Chen, Sheng; Wang, Wei; Ning, Bei-Fang; Chen, Fei; Shen, Weifeng; Ding, Jin; Chen, Wansheng; Xie, Wei-Fen; Zhang, Xin

Liu, Jiao; Chen, Sheng; Wang, Wei; Ning, Bei-Fang; Chen, Fei; Shen, Weifeng; Ding, Jin; Chen, Wansheng; Xie, Wei-Fen; Zhang, Xin.

Afiliación

Liu J; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Chen S; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Wang W; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Ning BF; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Chen F; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Shen W; Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai 200433, China.
Ding J; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China.
Chen W; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Xie WF; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. Electronic address: weifenxie@medmail.com.cn.
Zhang X; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. Electronic address: zhang68@hotmail.com.

Cancer Lett ; 379(1): 49-59, 2016 08 28.

Article en En | MEDLINE | ID: mdl-27216982

Asunto(s)

Fibroblastos Asociados al Cáncer/metabolismo; Carcinoma Hepatocelular/metabolismo; Movimiento Celular; Quimiocinas/metabolismo; Proteínas Hedgehog/metabolismo; Neoplasias Hepáticas/metabolismo; Comunicación Paracrina; Transducción de Señal; Factor de Crecimiento Transformador beta/metabolismo; Animales; Neoplasias Óseas/metabolismo; Neoplasias Óseas/secundario; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/secundario; Fibroblastos Asociados al Cáncer/patología; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/secundario; Línea Celular Tumoral; Quimiocina CCL2/metabolismo; Quimiocina CCL5/metabolismo; Quimiocina CCL7/metabolismo; Quimiocina CXCL16; Quimiocinas CXC/metabolismo; Proteínas Hedgehog/genética; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patología; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/secundario; Masculino; Ratones Endogámicos NOD; Ratones Desnudos; Ratones SCID; Invasividad Neoplásica; Receptores Depuradores/metabolismo; Factores de Tiempo; Transfección; Factor de Crecimiento Transformador beta/genética; Células Tumorales Cultivadas; Microambiente Tumoral

Palabras clave

Cancer-associated fibroblasts; Chemokines; Hedgehog pathway; Metastasis; TGF-ß pathway

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Movimiento Celular / Factor de Crecimiento Transformador beta / Carcinoma Hepatocelular / Quimiocinas / Comunicación Paracrina / Proteínas Hedgehog / Fibroblastos Asociados al Cáncer / Neoplasias Hepáticas Tipo de estudio: Risk_factors_studies Idioma: En Revista: Cancer Lett Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda

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