Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells.

Kulabas, Necla; Tatar, Esra; Bingöl Özakpinar, Özlem; Özsavci, Derya; Pannecouque, Christophe; De Clercq, Erik; Küçükgüzel, Ilkay

Kulabas, Necla; Tatar, Esra; Bingöl Özakpinar, Özlem; Özsavci, Derya; Pannecouque, Christophe; De Clercq, Erik; Küçükgüzel, Ilkay.

Afiliación

Kulabas N; Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydarpasa, 34668 Istanbul, Turkey.
Tatar E; Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydarpasa, 34668 Istanbul, Turkey.
Bingöl Özakpinar Ö; Marmara University, Faculty of Pharmacy, Department of Biochemistry, Haydarpasa, 34668 Istanbul, Turkey.
Özsavci D; Marmara University, Faculty of Pharmacy, Department of Biochemistry, Haydarpasa, 34668 Istanbul, Turkey.
Pannecouque C; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, B-3000 Leuven, Belgium.
De Clercq E; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, B-3000 Leuven, Belgium.
Küçükgüzel I; Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydarpasa, 34668 Istanbul, Turkey. Electronic address: ikucukguzel@marmara.edu.tr.

Eur J Med Chem ; 121: 58-70, 2016 Oct 04.

Article en En | MEDLINE | ID: mdl-27214512

Asunto(s)

Acetamidas/farmacología; Antineoplásicos/química; Apoptosis/efectos de los fármacos; Acetamidas/síntesis química; Antineoplásicos/farmacología; Proteínas Reguladoras de la Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Relación Estructura-Actividad; Triazoles

Palabras clave

1,2,4-Triazoles; Anticancer activity; Apoptosis; Bcl-2; Caspase-3; Caspase-8; Thioethers

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Acetamidas / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Francia

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