Natriuretic action of central angiotensin II in conscious rats.
Brain Res
; 486(1): 33-8, 1989 May 01.
Article
en En
| MEDLINE
| ID: mdl-2720433
The effects of intracerebroventricular (i.c.v.) injections of angiotensin II (ANG II, 10 pg, 100 pg and 10 ng) on renal sodium excretion were investigated in conscious rats instrumented with a chronic urethral catheter. ANG II increased renal sodium excretion dose-dependently with a threshold i.c.v. dose of 10 pg. Only after the highest dose was a concomitant increase in arterial blood pressure and urinary flow observed. The ANG II-induced natriuresis began within 5 min of the i.c.v. injection and lasted for more than 1 h. The angiotensin receptor antagonist saralasin (1 ng, i.c.v.) largely prevented the natriuretic effect of i.c.v. injected ANG II (100 pg). Our results lend further support to the hypothesis that brain ANG II by its potent natriuretic actions may be instrumental in central osmotic control.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sodio
/
Encéfalo
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Angiotensina II
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Países Bajos