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Late Pregnancy is a Critical Period for Changes in Phosphorylated Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase 1/2 in Oxytocin Neurones.
Chandaka, G K; Wang, L; Senogles, S; Armstrong, W E.
Afiliación
  • Chandaka GK; Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Wang L; Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Senogles S; Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Armstrong WE; Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
J Neuroendocrinol ; 28(9)2016 09.
Article en En | MEDLINE | ID: mdl-27203238
The physiological demands of parturition and lactation lead to the increased pulsatile release of oxytocin (OT) into the circulation from the neurohypophysial axons of OT neurones in the supraoptic (SON) and paraventricular (PVN) nuclei. These states of increased OT release are accompanied by a significant plasticity in magnocellular OT neurones and their synaptic connections, and many of these changes require activation of a central OT receptor. The mitogen-activated protein kinase/extracellular signal-regulated kinase pathway (MAPK/ERK) is assumed to be up-regulated in the PVN during lactation, and many of the effects of OT in peripheral and brain tissue are mediated through a MAPK/ERK pathway. The present study investigated whether this pathway is altered in the SON and PVN during late pregnancy [embryonic day (E)20-21], which is a critical period for OT plasticity induction, and for lactation, when plastic changes are sustained. Based on immunoreactivity for phosphorylated ERK1/2 (pERK1/2), the results suggest an enhanced activation of MAPK/ERK pathway in OT neurones specifically during late pregnancy in both the SON and PVN. Although immunoblots from the SON confirm this pregnancy-associated up-regulation in late pregnancy, they also suggest enhancement into lactation as well. Together, the results suggest an important role for the MAPK/ERK pathway during reproductive changes in the SON and PVN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Núcleo Hipotalámico Paraventricular / Núcleo Supraóptico / Embarazo / Oxitocina / Proteína Quinasa 1 Activada por Mitógenos / Proteína Quinasa 3 Activada por Mitógenos / Neuronas Límite: Animals Idioma: En Revista: J Neuroendocrinol Asunto de la revista: ENDOCRINOLOGIA / NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Núcleo Hipotalámico Paraventricular / Núcleo Supraóptico / Embarazo / Oxitocina / Proteína Quinasa 1 Activada por Mitógenos / Proteína Quinasa 3 Activada por Mitógenos / Neuronas Límite: Animals Idioma: En Revista: J Neuroendocrinol Asunto de la revista: ENDOCRINOLOGIA / NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos