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Association between IL-6 Gene (-174 & -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk.
Wang, Hai-Ying; Zhang, Jin-Jun; Zheng, Xiang-Yu; Liu, Jian-Hua; Li, Yong-Wei.
Afiliación
  • Wang HY; Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China.
  • Zhang JJ; Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China.
  • Zheng XY; Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China.
  • Liu JH; Department of Obstetrics and Gynecology, Shanghai Ninth People's Hospital & School of Medicine, Shanghai Jiaotong University, Shanghai, 200011, People's Republic of China. LIUJianh68@126.com.
  • Li YW; Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China. liyw71@126.com.
Pathol Oncol Res ; 22(4): 825-9, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27193105
We aimed to evaluate the association of IL-6 gene polymorphisms at positions of -174 and -572 and predisposition of endometrial adenocarcinoma (EAC) in a Chinese population. EAC patients have remarkably higher frequency of IL-6 -174 CC genotype [odds ratio (OR) =1.56, 95 % confidence interval (CI) =1.07-2.23; P = 0.03], IL-6 -572 CC genotype (OR =1.93, 95%CI =1.17-3.15; P = 0.01) and IL-6 -174 C allele (OR =1.22, 95 % CI =1.03-1.46; P = 0.04) compared with healthy controls. When stratified with FIGO stage, patients with III-IV EAC have a significantly higher frequency of IL-6 -174 CC genotype (OR =1.66, 95% CI =1.06-2.58; P = 0.02) than healthy controls. The CC genotype of IL-6 gene polymorphisms at positions of -174 and -572 may denote potential high risk of EAC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Adenocarcinoma / Interleucina-6 / Neoplasias Endometriales / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Pathol Oncol Res Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Adenocarcinoma / Interleucina-6 / Neoplasias Endometriales / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Pathol Oncol Res Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Suiza