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Prediction of outcome by lymph node ratio in patients with parotid gland cancer.
Meyer, M F; Kreppel, M; Meinrath, J; Grünewald, I; Stenner, M; Drebber, U; Quaas, A; Odenthal, M; Semrau, R; Huebbers, C U; Zöller, J; Huettenbrink, K-B; Buettner, R; Beutner, D.
Afiliación
  • Meyer MF; Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
  • Kreppel M; Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.
  • Meinrath J; Department of Pathology, University of Cologne, Cologne, Germany.
  • Grünewald I; Department of Pathology, University of Cologne, Cologne, Germany.
  • Stenner M; Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
  • Drebber U; Department of Pathology, University of Cologne, Cologne, Germany.
  • Quaas A; Department of Pathology, University of Cologne, Cologne, Germany.
  • Odenthal M; Department of Pathology, University of Cologne, Cologne, Germany.
  • Semrau R; Department of Radiation Oncology, University of Cologne, Cologne, Germany.
  • Huebbers CU; Jean-Uhrmacher Institute, University of Cologne, Cologne, Germany.
  • Zöller J; Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.
  • Huettenbrink KB; Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
  • Buettner R; Department of Pathology, University of Cologne, Cologne, Germany.
  • Beutner D; Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Clin Otolaryngol ; 42(1): 98-103, 2017 Feb.
Article en En | MEDLINE | ID: mdl-27185037
OBJECTIVE: Lymph node ratio (LNR) has been shown to be an independent predictor of recurrence risk and survival in different entities of carcinoma. METHODS: In this retrospective chart review, 128 patients with parotid gland cancer (PGC) subsequently treated by primary surgery were included. About 64% (n = 82) of these patients were additionally treated with adjuvant radiotherapy. Five-year overall survival rates were determined by subgroups based on LNR value. RESULTS: Lymph node ratio was found to be significantly associated with overall survival rate (P < 0.001). Using univariate analyses, pathological tumour-node-metastasis (TNM)-stage, UICC-stage grouping and extracapsular spread were found to be significant predictors of overall survival (P < 0.001). However, with a multivariate analyses, LNR remained the only independent predictor of overall survival (P = 0.043). CONCLUSIONS: After surgery for PGC, evaluation of the neck using LNR was found to reliably stratify the overall survival rate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Parótida / Carcinoma / Escisión del Ganglio Linfático / Ganglios Linfáticos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Otolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Parótida / Carcinoma / Escisión del Ganglio Linfático / Ganglios Linfáticos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Otolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido