Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.

Lu, Dongmei; Rauhauser, Alysha; Li, Binghua; Ren, Chongyu; McEnery, Kayla; Zhu, Jili; Chaki, Moumita; Vadnagara, Komal; Elhadi, Sarah; Jetten, Anton M; Igarashi, Peter; Attanasio, Massimo

Lu, Dongmei; Rauhauser, Alysha; Li, Binghua; Ren, Chongyu; McEnery, Kayla; Zhu, Jili; Chaki, Moumita; Vadnagara, Komal; Elhadi, Sarah; Jetten, Anton M; Igarashi, Peter; Attanasio, Massimo.

Afiliación

Lu D; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rauhauser A; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Li B; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ren C; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
McEnery K; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhu J; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Nephrology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
Chaki M; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vadnagara K; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Elhadi S; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jetten AM; Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Igarashi P; Department of Internal Medicine, University of Minnesota, Minneapolis, MN, USA.
Attanasio M; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Eugene McDermott Center for Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: massimo.attanasio@utsouthwestern.edu.

Kidney Int ; 89(6): 1307-23, 2016 06.

Article en En | MEDLINE | ID: mdl-27181777

Asunto(s)

Senescencia Celular/genética; Quistes/genética; Células Epiteliales/fisiología; Enfermedades Renales Quísticas/genética; Túbulos Renales/fisiología; Cinesinas/genética; Factores de Transcripción de Tipo Kruppel/fisiología; Proteínas del Tejido Nervioso/fisiología; Animales; Puntos de Control del Ciclo Celular/genética; Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1)/metabolismo; Cilios/patología; Daño del ADN/genética; Modelos Animales de Enfermedad; Células Epiteliales/citología; Fibrosis; Citometría de Flujo; Técnica del Anticuerpo Fluorescente; Humanos; Imidazoles/farmacología; Túbulos Renales/citología; Factores de Transcripción de Tipo Kruppel/genética; Ratones; Ratones Noqueados; Proteínas del Tejido Nervioso/genética; Fenotipo; Piperazinas/farmacología; Proteínas Proto-Oncogénicas c-mdm2/antagonistas & inhibidores; Interferencia de ARN; ARN Interferente Pequeño/genética; Proteína p53 Supresora de Tumor/metabolismo

Palabras clave

DNA damage; Kif3a; cystic kidney disease; nephronophthisis; senescence

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cinesinas / Senescencia Celular / Quistes / Células Epiteliales / Enfermedades Renales Quísticas / Factores de Transcripción de Tipo Kruppel / Túbulos Renales / Proteínas del Tejido Nervioso Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Kidney Int Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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