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A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans.
Romu, Thobias; Vavruch, Camilla; Dahlqvist-Leinhard, Olof; Tallberg, Joakim; Dahlström, Nils; Persson, Anders; Heglind, Mikael; Lidell, Martin E; Enerbäck, Sven; Borga, Magnus; Nystrom, Fredrik H.
Afiliación
  • Romu T; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
  • Vavruch C; Department of Medical and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University.
  • Dahlqvist-Leinhard O; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
  • Tallberg J; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
  • Dahlström N; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
  • Persson A; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
  • Heglind M; Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Lidell ME; Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Enerbäck S; Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Borga M; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
  • Nystrom FH; Department of Medical and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University. Electronic address: fredrik.h.nystrom@liu.se.
Metabolism ; 65(6): 926-34, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27173471
OBJECTIVE: To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze. DESIGN: Randomized, open, parallel-group trial. METHODS: Healthy non-selected participants were randomized to achieve cold-exposure 1hour/day, or to avoid any sense of feeling cold, for 6weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI). RESULTS: Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841±199 kCal/24h to 1795±213 kCal/24h, p=0.047 cold-activated MR from 1900±150 kCal/24h to 1793±215 kCal/24h, p=0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p=0.052). The difference between MR changes by the interventions between groups was statistically significant (p=0.008 at room temperature, p=0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported ≥8days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175±0.015l to 0.0216±0.014l, p=0.049). CONCLUSIONS: We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Frío / Termogénesis / Metabolismo Energético Tipo de estudio: Clinical_trials / Health_economic_evaluation Límite: Adult / Female / Humans / Male Idioma: En Revista: Metabolism Año: 2016 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Frío / Termogénesis / Metabolismo Energético Tipo de estudio: Clinical_trials / Health_economic_evaluation Límite: Adult / Female / Humans / Male Idioma: En Revista: Metabolism Año: 2016 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos